Andrographolide Induces Mitochondrial Dysfunction and Alters Stemness-related Gene Expression in MCF7 Breast Cancer Cells [0.03%]
andrographolide通过诱导线粒体功能障碍和改变乳腺癌MCF7细胞的干性相关基因表达发挥抗肿瘤作用
Natthima Suwan,Sasipat Teerawongsuwan,Sirinya Jenjittikul et al.
Natthima Suwan et al.
Background/aim: Andrographolide, a compound derived from Andrographis paniculata, has exhibited promising antineoplastic effects; however, its effects on pluripotency and cancer stemness remain unclear. Since pluripotency...
Risk Factor Analysis for Bevacizumab-induced Severe Hypertension in Advanced Breast Cancer Treatment [0.03%]
贝伐单抗致严重高血压的风险因素分析（晚期乳腺癌治疗中）
Yoshihiko Sugino,Hiroaki Sakurada,Misako Baba et al.
Yoshihiko Sugino et al.
Background/aim: Bevacizumab (BV) is used in combination with paclitaxel to treat human epidermal growth factor receptor 2-negative advanced breast cancer. However, BV frequently causes hypertension. Because patients with ...
Effect of Recombinant Methioninase Dose and Timing on the Selective and Precise Elimination of Cancer Cells from Co-Cultured Normal Cells and on Methionine-dependent Rescue of Cancer Cells [0.03%]
重组蛋氨酸脱氨酶的剂量和给药时间对从共培养正常细胞中选择性精确消除癌细胞及对甲硫氨酸依赖型癌细胞救援的影响
Jinsoo Kim,Qinghong Han,Shukuan Li et al.
Jinsoo Kim et al.
Background/aim: Methionine addiction is a fundamental and general hallmark of cancer, known as the Hoffman effect. The aim of the present study was to target methionine addiction of cancer cells co-cultured with normal ce...
BHLHE41 Enhances Gemcitabine Sensitivity of Pancreatic Cancer Cells Through IGFBP4 Suppression [0.03%]
BHLHE41通过抑制IGFBP4增强胰腺癌细胞对吉西他滨的敏感性
Hisaaki Shii,Kentaro Minami,Ryu Takeya et al.
Hisaaki Shii et al.
Background/aim: Pancreatic cancer (PC) has a poor prognosis and limited treatment options. The development of resistance to anticancer agents poses a significant challenge in the treatment of PC. Our previous study indica...
Methionine Restriction, Not Cysteine Restriction, Is a Cancer-specific Vulnerability [0.03%]
甲硫氨酸限制而非半胱氨酸限制是一种癌症特异性弱点
Yuta Miyashi,Kohei Mizuta,Yohei Asano et al.
Yuta Miyashi et al.
Background/aim: Recently, there have been numerous publications on the induction of ferroptosis by cysteine restriction in cancer cells. The present report aimed to determine whether cysteine restriction (CR) is a cancer-...
Study on the Synthesis and Structure-activity Relationship of 3-Styrylflavones Possessing Variously Hydroxylated D-ring Moiety [0.03%]
具有不同D环取代的3-茋黄酮类化合物的合成及其构效关系研究
Arisa Tsutsumi,Satoru Kawaii,Yuko Yoshizawa
Arisa Tsutsumi
Background/aim: Flavones are known as a prominent subclass within the flavonoid family and occupy an important part of the human diet. Their distinctive structure has been considered to show the activities and thus they r...
Impact of Chronic Kidney Disease on End-stage Renal Disease After Treatment for Localized Renal Cell Carcinoma [0.03%]
慢性肾脏病对局部肾细胞癌治疗后终末期肾病的影响
Shunta Hori,Tomonori Nakahama,Mitsuru Tomizawa et al.
Shunta Hori et al.
Background/aim: Partial or radical nephrectomy are the gold standard treatments for localized renal cell carcinoma; however, these treatments can induce kidney disease. This study aimed to investigate the functional outco...
TTF-1 Expression and Efficacy of Platinum and Pemetrexed Plus Pembrolizumab in Advanced Lung Adenocarcinoma [0.03%]
TTF-1表达与晚期肺腺癌铂类及培美曲塞联合帕博利珠单抗的疗效关系研究
Yosuke Tamura,Shigeru Kawabata,Ryutaro Yamaguchi et al.
Yosuke Tamura et al.
Background/aim: Thyroid transcription factor-1 (TTF-1) negativity is a poor prognostic factor for patients with lung adenocarcinoma. Platinum and pemetrexed have inferior therapeutic efficacy compared to other chemotherap...
Association Between Human Papillomavirus Infection Status and Coronary Artery Calcification in Patients With Oropharyngeal Cancer [0.03%]
人乳头瘤病毒感染状态与口咽癌患者冠状动脉钙化之间的关系
Tomoaki Nishikawa,Akinori Higaki,Sohei Mitani et al.
Tomoaki Nishikawa et al.
Background/aim: Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPC); however, its role in atherosclerosis remains controversial. This study aimed to investigate the association between HPV typ...