Glucose Deprivation of Tumor Cells via Selective Nutrient Delivery: A Potential Therapy for Metastatic Breast Cancer [0.03%]
通过选择性营养输送剥夺肿瘤细胞的葡萄糖：转移性乳腺癌的一种潜在疗法
Kamran Shirbache,Kimiya Shirbacheh,Ali Rezvani et al.
Kamran Shirbache et al.
Background/aim: Metastatic breast cancer remains a major clinical challenge despite the availability of various chemotherapeutic agents. Current metabolic inhibitors have limitations, prompting the need for innovative str...
Extracellular cGMP Levels Predict the Response of C4-1 Cervical Cancer Cells to Ionizing Radiation [0.03%]
细胞外cGMP水平预测离子辐射对C4-1宫颈癌细胞的反应
Georg Sager,Marit Livik,Turid Hellevik et al.
Georg Sager et al.
Background/aim: Urine cyclic guanosine monophosphate (cGMP) has been proposed as a prognostic biomarker for therapy response and the risk of relapse of cervical cancer after treatment with radiotherapy (RT). In the presen...
Artery-first Approach Versus Standard Pancreaticoduodenectomy: A Systematic Review and Meta-analysis of Surgical Outcomes and Oncological Benefits [0.03%]
动脉优先法与标准胰十二指肠切除术的系统评价和meta分析：手术结果及肿瘤学优势的比较
Michail Skandalakis,Nikolaos Gonidakis,Maria Koundouraki et al.
Michail Skandalakis et al.
Background/aim: Pancreaticoduodenectomy (PD) is the standard curative option for pancreatic head carcinoma, but R1 resections remain frequent. The superior mesenteric artery (SMA) "artery-first" approach (AFA) may improve...
Sialic Acid-Fibronectin-negative and CD-44-positive Pancreatic Cancer Has a Poor Prognosis Due To Epithelial-Mesenchymal Transition [0.03%]
由于上皮间质转化腮蛋白-纤连蛋白阴性和CD44阳性胰腺癌预后不良
Takeshi Gocho,Hiroshi Takeyama,Yoshinobu Manome et al.
Takeshi Gocho et al.
Background/aim: Increases in cellular fibronectin (C-FN) in the stroma have been identified as one of the factors that induce epithelial-mesenchymal transition (EMT), which enhances cancer malignancy. We measured blood le...
Stereotactic Body Radiation Therapy for Spinal Metastasis Using Biaxially Rotational Dynamic Radiation Therapy (BROAD-RT) [0.03%]
应用立体定向脊柱放射治疗(BROAD-RT)治疗脊髓转移瘤
Akira Ueta,Rihito Aizawa,Yuka Ono et al.
Akira Ueta et al.
Background/aim: This study aimed to report clinical outcomes of spine stereotactic body radiation therapy (SBRT) using biaxially rotational dynamic radiation therapy (BROAD-RT), which is a novel non-coplanar volumetric-mo...
THEMIS2 as a Novel Mediator of VEGFR2-driven Angiogenesis in Breast Cancer: Functional Suppression by miR-125b-5p [0.03%]
乳腺癌中THEMIS2作为VEGFR2驱动的血管生成的新介质及其功能被miR-125b-5p抑制
Che-Ju Chang,Shiao-Lin Tung,Wan-Ting Liao et al.
Che-Ju Chang et al.
Background/aim: THEMIS2, a protein that plays a role in immune regulation, has recently been identified as a key factor in breast cancer progression. This study aimed to identify novel oncogenic regulators in circulating ...
Radiological Complete Response as a Prognostic Marker in HR-positive Metastatic Breast Cancer Treated With CDK4/6 Inhibitors: Implications for Treatment De-escalation [0.03%]
cyclin依赖性激酶4和6抑制剂治疗HR阳性转移性乳腺癌的放射学完全缓解的预后意义：对降级治疗的启示
Wataru Goto,Shinichiro Kashiwagi,Mariko Nishikawa et al.
Wataru Goto et al.
Background/aim: Endocrine therapy combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) is standard first-line treatment for hormone receptor (HR)-positive metastatic breast cancer (MBC). Although radiological co...
Curative Surgery Following Induction Chemotherapy for Sinonasal Small Cell Neuroendocrine Carcinoma With Contraindication to Radiotherapy [0.03%]
化疗诱导下的鼻窦小细胞神经内分泌癌根治性手术治疗(放疗禁忌者)
Po-Wen Wu,Huai-Pao Lee,Yu-Hsuan Lin
Po-Wen Wu
Background: Sinonasal small cell neuroendocrine carcinoma (SCNEC) is a rare and aggressive tumor lacking standardized treatment. While concurrent chemoradiotherapy or surgery with adjuvant therapy is commonly employed, th...
Impact of the Pre-radiotherapy Volume of the Urinary Bladder on its Filling Status During Hypo-fractionated Treatment for Prostate Cancer [0.03%]
放疗前尿膀胱体积对前列腺癌患者低分割治疗期间膀胱充盈状态的影响分析
Dirk Rades,Stefan Janssen,Cathrin Thieme et al.
Dirk Rades et al.
Background/aim: Many patients with prostate cancer receive moderately hypo-fractionated radiotherapy (mHF-RT). Inappropriate bladder filling during the mHF-RT course increases urinary toxicity. This study investigated the...
Efficacy and Safety of Subcutaneous Pertuzumab-Trastuzumab (Phesgo) in Neoadjuvant Treatment of HER2-positive Breast Cancer: Real-world Data from Japan [0.03%]
日本HER2阳性乳腺癌新辅助治疗中皮下注射帕妥珠单抗曲妥珠单抗固定剂量联合制剂(飞速达)的有效性和安全性：真实世界数据
Haruhito Kinoshita,Shinichiro Kashiwagi,Mariko Nishikawa et al.
Haruhito Kinoshita et al.
Background/aim: Subcutaneous fixed-dose combination of pertuzumab and trastuzumab (Phesgo) has been recently introduced as an alternative to intravenous administration in the treatment of HER2-positive breast cancer. Alth...