The Privileged Scaffold Quinoline in Derivatives With Anticancer Potential Mediated by Late Apoptosis [0.03%]
具有抗肿瘤潜能的晚期凋亡介导喹啉衍生物的特权支架
Denise Diedrich,Elenilson F Silva,Julia B Willig et al.
Denise Diedrich et al.
Background/aim: Cancer has been described as the perennial second leading cause of death, despite advances in detection and treatment. Considering this disease remains a major public health crisis across the world, scient...
Adenosine Inhibits Cholangiocarcinoma by a Concurrent Activation of AMPK and mTORC1 Signaling Pathways [0.03%]
腺苷通过同时活化AMPK和mTORC1信号通路抑制胆管癌
Jomnarong Lertsuwan,Jisnuson Svasti,Jutamaad Satayavivad
Jomnarong Lertsuwan
Background/aim: Cholangiocarcinoma (CCA) is a highly aggressive cancer for which current chemotherapies offer limited effectiveness. However, recent research suggests a promising new approach using adenosine. Studies have...
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial [0.03%]
七种微营养素联合治疗胶质母细胞瘤患者的总生存期：一种保健品试验
Harcharan Kaur Rooprai,Patrick Lawrence,Keyoumars Ashkan et al.
Harcharan Kaur Rooprai et al.
Background/aim: There is increasing evidence for recognition of nutraceuticals as anti-tumour agents in various cancers. Over the years, anecdotal reports and our laboratory-based research have indicated their promising t...
Clinical Trial
Anticancer research. 2026 Mar;46(3):1599-1608. DOI:10.21873/anticanres.18055 2026
Iodine-Hoechst Enhances X-ray Sensitivity of Cancer Cells Under Normal and Low Oxygen Conditions [0.03%]
碘化物和Hoechst联合增强癌细胞正常氧浓度和低氧浓度的X射线敏感性
Yuya Higashi,Momoka Goda,Saya Kobayashi et al.
Yuya Higashi et al.
Background/aim: Iodine-Hoechst (IH) is a derivative of Hoechst dye that binds minor grooves of DNA. This chemical has been used for cell labeling studies such as nuclear staining; however, its use in radiation therapy has...
Effectiveness of a Physician-Pharmacist Collaborative Protocol for Universal Hepatitis B Virus Screening Prior to Chemotherapy in Cancer Patients [0.03%]
肿瘤患者化疗前实施乙型肝炎病毒普遍筛查的医嘱合作协议之有效性研究
Hiroko Kato-Hayashi,Kenji Imai,Masayuki Ishida et al.
Hiroko Kato-Hayashi et al.
Background/aim: This study investigated the effectiveness of a protocol-based pharmacotherapy management (PBPM) system in preventing hepatitis B virus (HBV) reactivation induced by chemotherapy. ...
Immature Peritumoral Tertiary Lymphoid Structures Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After NAC [0.03%]
新辅助治疗后胰腺导管腺癌周围的不成熟瘤周三级淋巴器官结构提示预后不良
Mari Nabeya,Masao Nakajima,Ryouichi Tsunedomi et al.
Mari Nabeya et al.
Background/aim: Tertiary lymphoid structures (TLSs) have prognostic relevance in various cancers; however, the relationship is complex and depends on TLS properties. In this study, we evaluated the prognostic significance...
Gallic Acid as a Non-cytotoxic Modulator of the ROS-EGFR-ERK-EMT Axis in Xenograft-derived T98G Glioblastoma Cells [0.03%]
没食子酸通过调节ROS-EGFR-ERK-上皮间质转化轴抑制异种移植来源的T98G胶质母细胞瘤细胞中的肿瘤生长而不具有细胞毒性
Yu-Feng Su,Huey-Jiun Ko,Wei-Chung Chen et al.
Yu-Feng Su et al.
Background/aim: Glioblastoma (GBM) cells that adapt to the in vivo microenvironment often display enhanced invasion driven by EGFR-ERK signaling and epithelial-mesenchymal transition (EMT). This study aimed to characteriz...
Concurrent Pemetrexed With EGFR-TKI Slows the Accumulation of De Novo Mutations During In Vitro Exposure [0.03%]
Concurrent Pemetrexed与EGFR-TKI可减缓体外暴露过程中新发突变的累积
Eshat F Haque,Ryosuke Tanino,Tamio Okimoto et al.
Eshat F Haque et al.
Background/aim: Resistance to targeted therapy limits its efficacy in non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Although concurrent administration of pemetrexed (PEM) ...
Prediction of Pathological Response and Prognosis After Surgery by Tumor Reduction During Neoadjuvant Chemotherapy in Patients With Esophageal Squamous Cell Carcinoma [0.03%]
新辅助化疗食管鳞癌患者的肿瘤缩小预测术后病理缓解和预后
Nao Kitasaki,Yoichi Hamai,Ryosuke Hirohata et al.
Nao Kitasaki et al.
Background/aim: Neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (NAC-DCF) is the standard treatment for locally advanced esophageal squamous cell cancer (ESCC) in Japan; however, reliable markers fo...
Cytostatic Benzylidene-isophthaloylhydazides With Diminished Neurotoxicity [0.03%]
降低神经毒性的细胞静止苯并异香豆素杂环化合物类化合物
Mohammad Hossain,Ross A Filbrun,Shayne M Roth et al.
Mohammad Hossain et al.
Background/aim: Benzylidene-isophthaloylhydrazides possess functional groups capable of thiol alkylation, hydrogen bonding, and van der Waals interactions, making them promising scaffolds for anticancer drug design. This ...