Deletion of major shell proteins of ethanolamine utilization microcompartment reduces intrinsic antibiotic resistance, biofilm, and intracellular survival of Salmonella Typhimurium [0.03%]
乙醇胺利用微隔间主要壳蛋白的缺失可降低泰密菌沙门氏菌的固有抗生素抗性、生物膜和胞内存活能力
Minal R Bhalerao,Aishwarya S Davkhar,Ajit R Sawant et al.
Minal R Bhalerao et al.
With the high rise in Salmonella infections and emergence of antibiotic resistance, developing a novel strategy to control the pathogen is imperative. Earlier studies have revealed that ethanolamine (EA) metabolism plays a crucial role in S...
Dynamic exometabolomics reveals metabolic adaptations of Staphylococcus epidermidis to pH-mimicking skin and bloodstream [0.03%]
动态代谢组学揭示了表皮葡萄球菌对皮肤和血液微环境的代谢适应性
Elisabete Morais,Ana M Gil,Maria Miragaia et al.
Elisabete Morais et al.
Staphylococcus epidermidis (SE) is a common human skin coloniser, which is often the cause of medical device-associated infections. SE population is composed of two clonal lineages, A/C and B, with distinct pathogenic potential. Although pH...
João Pedro Gomes Greco,Natasha Rodrigues de Oliveira,Odir Antônio Dellagostin et al.
João Pedro Gomes Greco et al.
Leptospira interrogans, the agent of leptospirosis, employs complex virulence mechanisms that are not fully understood at a systems level. To elucidate the regulatory landscape of its pathogenicity, we used Weighted Gene Co-expression Netwo...
Differential DNA methylation associated with virulence attenuation in Edwardsiella piscicida [0.03%]
威权减弱相关的Edwardsiella piscicida差异DNA甲基化
Eun Gyeong Lee,Ki Hong Kim
Eun Gyeong Lee
A marked difference in virulence was observed between two subpopulations of the Edwardsiella piscicida FSW910410 strain, originally isolated from olive flounder (Paralichthys olivaceus). While the strain maintained under routine laboratory ...
Klebsiella pneumoniae-Induced Pneumonia: Pathogenesis, Immune Interactions, and Antimicrobial Resistance in a Global Context [0.03%]
肺炎克雷伯菌致肺炎的全球流行病学、发病机制和免疫调控及耐药性综述
Tasmia Jahin Mim,Amjad Islam Aqib,Abdullah Al Noman et al.
Tasmia Jahin Mim et al.
Klebsiella pneumoniae is a Gram-negative bacterium and an important pathogen implicated in both hospital- and community-acquired pneumonia. K. pneumoniae strains are either classical, hypervirulent (hvKp), or antibiotic-resistant. There are...
Investigating inhibitory effect of sterol targeting compounds against B. anthracis: Membrane Microdomain a probable target [0.03%]
抑菌筛选结合甾醇正向遗传学分析方法研究贝宁棒状杆菌抑制剂的作用机制：甾醇定位化合物的膜微区可能是作用靶点
Vikas Kumar Somani,Somya Aggarwal,V S Radhakrishnan et al.
Vikas Kumar Somani et al.
Purpose: This study aimed to evaluate the role of membrane microdomains (MMd) in virulence of Bacillus anthracis by assessing the effects of known antifungal compounds, referred to as raft-associated lipid biosynthesis in...
Regulatory network of nucleotide second messenger in Pseudomonas aeruginosa PFL-P1 and intercellular signaling molecules for functional amyloid fibrillation in biofilm and stress response [0.03%]
铜绿假单胞菌PFL-P1的核苷酸第二信使调控网络及其生物被膜和应激反应中的细胞间信号分子
Swetambari Kumari,Surajit Das
Swetambari Kumari
Biofilm formation is governed by quorum sensing (QS) and intracellular signaling, with cyclic di-GMP (c-di-GMP) acting as a key regulator that modulates biofilm stability in response to environmental cues. The present study aims to explore ...
D Rani Prameela,Lahari,S Vijayalakshmi et al.
D Rani Prameela et al.
Over the years, anthrax has become endemic in the state of Andhra Pradesh, Indiaposing risk for both animals and humans and spreading to the bordering state of Karnataka. Theincidence is on the rise and the spread coveringthe entire state.T...
An electron microscopy study of Bacillus anthracis capsule reveals early expression and novel strand-like structures [0.03%]
电镜研究揭示炭疽芽孢杆菌荚膜的早期表达及新型丝状结构
Wilson J Ribot,Robert K Pope,Donald J Chabot et al.
Wilson J Ribot et al.
Capsule is a key virulence factor for Bacillus anthracis. In this study, we examined the onset of capsule expression and the ultrastructure of capsule expressed in vitro and in infected hosts. We determined by immunofluorescence and immunoe...
Molecular analysis of Bacillus anthracis isolates from Karnataka's ruminant Anthrax outbreaks reveals genetic relationships and environmental factors Influencing spore persistence [0.03%]
分子分析揭示了卡纳塔克邦反刍动物炭疽爆发中的芽孢杆菌遗传关系及环境因素对孢子持久性的影响
Chaitra Bai K T,Shivaraj Murag,Manohar Raju V et al.
Chaitra Bai K T et al.
Background: Anthrax outbreaks continue to be reported from several districts of Karnataka in India. Many outbreaks in livestock and humans have reported, the soil and climatic conditions would have supported long-term spo...