Sukhbir Kaur,Jeffrey S Isenberg,David D Roberts
Sukhbir Kaur
CD47, also known as integrin-associated protein, is a constitutively and ubiquitously expressed transmembrane receptor. CD47 is conserved across amniotes including mammals, reptiles, and birds. Expression is increased in many cancers and, i...
Mary J Underdown,Thomas B Russell,Mark J Pettenati et al.
Mary J Underdown et al.
Dicentric (7;9)(p11-13;p11) is a rare but recurrent abnormality in pediatric and adult precursor B acute lymphoblastic leukemia (B-ALL). The rarity precludes a deep understanding of its biology and associated prognosis. However, recent find...
Jeffrey S Isenberg,David D Roberts
Jeffrey S Isenberg
Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncoge...
Caileigh Pudela,Skye Balyasny,Mark A Applebaum
Caileigh Pudela
Neuroblastoma is a clinically heterogenous pediatric cancer of the sympathetic nervous system that originates from neural crest cells. It is the most common extracranial solid tumor in childhood and prognosis ranges from spontaneous tumor r...
Helmut Hanenberg,Paul R Andreassen
Helmut Hanenberg
PALB2 (Partner and Localizer of BRCA2) was first identified as a BRCA2-interacting protein. Subsequently, PALB2 has been recognized as a cog in the cellular machinery for DNA repair by homologous recombination (HR). PALB2 also mediates S an...
Paul R Andreassen,Helmut Hanenberg
Paul R Andreassen
XRCC2 is one of five somatic RAD51 paralogs, all of which have Walker A and B ATPase motifs. Each of the paralogs, including XRCC2, has a function in DNA double-strand break repair by homologous recombination (HR). However, their individual...
Yash R Somnay,David Schneider,Haggi Mazeh
Yash R Somnay
Medullary thyroid cancers (MTC) are rare neuroendocrine tumors arising from the parafollicular C-cells of the thyroid. In this review, we provide a general overview of the classification, pathology, and clinical management of MTC. In the la...
Lymphangioleiomyomatosis [0.03%]
淋巴管平滑肌瘤病
Angelo M Taveira-DaSilva,Wendy K Steagall,Joel Moss
Angelo M Taveira-DaSilva
Yulei Zhao,Xiaolong Yang
Yulei Zhao
WWTR1 (also called TAZ in publications. Therefore, TAZ is used in the following description) is a WW domaing-containing transcriptional coactivator, which was first identified as a 14-3-3 binding protein. TAZ is the downstream component in ...