Synthesis of Disulfide-Bridging Trehalose Polymers for Antibody and Fab Conjugation Using a Bis-Sulfone ATRP Initiator [0.03%]
用于抗体和Fab偶联的双磺酸ATRP引发剂合成二硫键连接的海藻糖聚合物
Neil L Forsythe,Heather D Maynard
Neil L Forsythe
Antibodies and antigen binding fragments (FABs) are widely used as therapeutics and conjugated polymers can enhance the properties of these important biomolecules. However, limitations to the selectivity and stability of current conjugation...
Synthesis of water-soluble surfactants using catalysed condensation polymerisation in green reaction media [0.03%]
催化条件下绿色介质中合成长链二元酸的缩聚反应制备水溶性表面活性剂
Amy R Goddard,Edward A Apebende,Joachim C Lentz et al.
Amy R Goddard et al.
Sustainable and biobased surfactants are required for a wide range of everyday applications. Key drivers are cost, activity and efficiency of production. Polycondensation is an excellent route to build surfactant chains from bio-sourced mon...
Co-assembly of precision polyurethane ionomers reveals role of and interplay between individual components [0.03%]
高精度聚氨酯离子缔合物的协同组装揭示了各组分的作用及相互作用
Elizabeth M Timmers,P Michel Fransen,Álvaro González García et al.
Elizabeth M Timmers et al.
Industrial and household products, such as paints, inks and cosmetics usually consist of mixtures of macromolecules that are disperse in composition, in size and in monomer sequence. Identifying structure-function relationships for these sy...
Expanding the Thiol-X Toolbox: Photoinitiation and Materials Application of the Acid-Catalyzed Thiol-ene (ACT) Reaction [0.03%]
扩展硫醇-x工具箱：酸催化硫醇烯反应的光引发及材料应用
Bryan P Sutherland,Mukund Kabra,Christopher J Kloxin
Bryan P Sutherland
The acid-catalyzed thiol-ene reaction (ACT) is a unique thiol-X conjugation strategy that produces S,X-acetal conjugates. Unlike the well-known radical-mediated thiol-ene and anion-mediated thiol-Michael reactions that produce static thioet...
Optimization of Ring-Opening Metathesis Polymerization (ROMP) under Physiologically Relevant Conditions [0.03%]
生理条件下环氧化合物开环易位聚合(ROMP)的优化研究
Derek C Church,Lauren Takiguchi,Jonathan K Pokorski
Derek C Church
Ring opening metathesis polymerization (ROMP) is widely considered an excellent living polymerization technique that proceeds rapidly under ambient conditions and is highly functional group tolerant when performed in organic solvents. Howev...
Jerry J Y Chen,A J van der Vlies,U Hasegawa
Jerry J Y Chen
Hydrogen sulfide (H2S), an important gaseous signalling molecule in the human body, has been shown to be involved in many physiological processes such as angiogenesis. Since the biological activities of H2S are known to be significantly aff...
Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems [0.03%]
生物系统中前药激活的实时MRI检测用脯有机自由基对比剂(“pro-ORCAs”)
Hung V-T Nguyen,Alexandre Detappe,Peter Harvey et al.
Hung V-T Nguyen et al.
Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe, next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been rep...
Impact of Backbone Composition on Homopolymer Dynamics and Brush Block Copolymer Self-Assembly [0.03%]
主体组成对同聚物动力学及梳状嵌段共聚物自组装的影响
Bret M Boyle,Joseph L Collins,Tara E Mensch et al.
Bret M Boyle et al.
Four series of brush block copolymers (BBCP), with near identical side chain compositions but varying backbone structures, were synthesized to investigate the effect of backbone structure on the process of thermal BBCP self-assembly to phot...
Impacts of Performing Electrolysis During Organocatalyzed Atom Transfer Radical Polymerization [0.03%]
在有机催化原子转移自由基聚合过程中进行电解的影响
Daniel A Corbin,Blaine G McCarthy,Garret M Miyake
Daniel A Corbin
An electrochemical variant of organocatalyzed atom transfer radical polymerization (O-ATRP) is developed and investigated. Inspired by electrochemically mediated atom transfer radical polymerization (eATRP), potentiostatic electrolysis is u...
Synthesis of a Heterotelechelic Helical Poly(methacrylamide) and its Incorporation into a Supramolecular Triblock Copolymer [0.03%]
合成一种杂端肽环状聚(甲基丙烯酰胺)及其超分子三嵌段共聚物的引入
Ru Deng,Margarita Milton,Scott K Pomarico et al.
Ru Deng et al.
We report the first heterotelechelic helical poly(methacrylamide) (PMAc) bearing orthogonal supramolecular binding sites on its chain-ends synthesized through a combination of reversible addition-fragmentation chain-transfer (RAFT) polymeri...