A highly sensitive LC-MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study [0.03%]
一种大鼠血浆、肝肾组织中AB-38b的定量分析高灵敏度LC-MS/MS方法及其在药代动力学研究中的应用
Dandan Pan,Libang Chen,Haonan Luo et al.
Dandan Pan et al.
Our research team developed AB-38b, a biphenyl diester derivative containing α,β-unsaturated carbonyl groups, inspired by investigations into the pharmacological prevention and pathophysiology of diabetic kidney disease (DKD). We have com...
Zn-MOF-8-based nitrogen-doped mesoporous carbon/multi-walled carbon nanotube-modified electrodes for highly sensitive detection of isoquercitrin [0.03%]
基于Zn-MOF-8的氮掺杂介孔碳/多壁碳纳米管修饰电极用于异鼠李素的高灵敏检测
Wei Liu,Zi Li,Hongfang Li et al.
Wei Liu et al.
In this study, nitrogen-doped mesoporous carbon (NMC) was synthesized using Zn-MOF-8 as a template, followed by further reaction with multi-walled carbon nanotubes (MWCNTs) to prepare the NMC/MWCNTs nanocomposite. Characterization of the co...
Analytical applications of gas-phase ion chemistry enabled by mass spectrometry [0.03%]
质谱引导的气相离子化学在分析中的应用
Woo-Young Kang,Boone M Prentice
Woo-Young Kang
Analytical mass spectrometry (MS) has been employed to study a wide variety of analytes, including metabolites, lipids, pharmaceutical compounds, pesticides, petroleum, peptides, proteins, protein complexes, nucleic acids, and glycans. The ...
Analytical Methods Committee Amctb No
Analytical Methods Committee Amctb No
Air pollution remains a matter of concern for governments, regulators and the public. Particulate matter (PM) is an important pollutant in this respect, and its composition is thought to be the most critical aspect with regard to its effect...
An integrated magnetic-microfluidic chemiluminescence platform for rapid quantification of exosomal miR-21 associated with breast cancer [0.03%]
一种集成磁微流控化学发光平台快速量化与乳腺癌相关外泌体miR-21的方法
Samira Narimani Kohnehshahri,Fatemeh Etezadi,Mohammad Amin Hajari et al.
Samira Narimani Kohnehshahri et al.
Accurate quantification of microRNAs (miRNAs) is crucial for early cancer diagnosis, but conventional techniques, such as quantitative PCR and microarrays, are time-consuming, costly, and require complex instrumentation. In this study, we d...
Quantitative sampling of iodinated X-ray contrast media in water by diffusive gradients in the thin-films technique [0.03%]
薄膜技术测定水溶液中含碘造影剂的扩散梯度定量采样法
Chenxi Yin,Xiaoyang Cai,Jia Dong et al.
Chenxi Yin et al.
Iodinated X-ray contrast media (ICM) have emerged as persistent contaminants due to their high polarity, persistence and biological inertness. In this work, a sampling method for monitoring the time-integrated concentrations of six ICMs, io...
Nanosensors as diagnostic tools: emerging concepts, opportunities, and design barriers [0.03%]
纳米传感器作为诊断工具：新兴概念、机遇和设计障碍
Babatunde Olamide Omiyale,Akinola Ogbeyemi,Muhammad Awais Ashraf et al.
Babatunde Olamide Omiyale et al.
Nanosensors have become a revolutionary tool, enabling early diagnosis and continuous monitoring of diseases with high accuracy. These tiny devices, operating at the nanoscale (typically between 1 and 100 nm), serve as signal generators to ...
Random forest models accurately classify synthetic opioids using high-dimensionality mass spectrometry datasets [0.03%]
随机森林模型利用高维质谱数据准确分类合成阿片类药物
Kourosh Arasteh,Steven Magana-Zook,Colin V Ponce et al.
Kourosh Arasteh et al.
Detection of novel threat agents presents several challenges, a principle one being the development of untargeted methods to screen an increasing number of threat chemicals whose exact structures are unknown. With the use of Machine Learnin...
Tyrosinase detection via enzyme-triggered structural transformation of a ratiometric fluorescent probe [0.03%]
基于酶触发的比率型荧光探针结构变换的酪氨酸酶检测法
Minwoo Han,Haemin Choi,Juyeon Cha et al.
Minwoo Han et al.
Tyrosinase is a key biomarker in melanoma, emphasizing the need for reliable detection. Here, we developed a ratiometric fluorescent probe that undergoes enzyme-triggered structural transformation, evidenced by HPLC and spectral changes. It...
Establishment and application of a method for detecting tetracycline antibiotics in milk based on AlphaLICA technology [0.03%]
基于AlphaLICA技术的牛奶中四环素类抗生素残留检测方法建立及应用研究
Dian Li,Yun Chen,Shangbin Kao et al.
Dian Li et al.
Addressing the challenges of strong matrix interference, cumbersome procedures, and urgent demand for on-site rapid detection in the analysis of tetracycline antibiotic (TCA) residues in milk, this study aims to develop an efficient, rapid ...