Development of a novel MSRE-dPCR assay for non-invasive prenatal testing of trisomy 21 [0.03%]
用于非侵入性产前检测21三体的新型MSRE-dPCR检测方法的研究与发展
Chunmao Lin,Tan Wang,Boyang Han et al.
Chunmao Lin et al.
Currently, next-generation sequencing (NGS)-based non-invasive prenatal diagnosis testing (NIPT) of fetal T21 has been proven to be much more advantageous than traditional serum biochemical tests in terms of accuracy and sensitivity. Nevert...
Estimation of the metabolic stability of omipalisib in human liver microsomes employing an ultra-fast UPLC-MS/MS approach: in silico screening for structural alarms and metabolic lability [0.03%]
基于超快UPLC-MS/MS方法的人肝微粒体中omipalisib代谢稳定性的研究：结构警示和代谢不稳定性的计算机筛选
Mohamed W Attwa,Awadh M Ali,Ali S Abdelhameed et al.
Mohamed W Attwa et al.
Omipalisib (OMP) is a powerful dual inhibitor of the mTOR and PI3K enzymes, demonstrating anti-tumor effectiveness in multiple cancer types. No reported UPLC-MS/MS method with in silico metabolism analysis and combined green metrics has bee...
Alkaline extraction with tetramethylammonium hydroxide for mercury determination in fish samples by CV-MIP AES as an alternative to conventional sample preparation methods [0.03%]
四甲胺氢氧化物碱提取结合CV-MIP AES测定鱼样中的汞含量可作为传统样品前处理方法的替代品
Fiorella Iaquinta,Alicia Mollo
Fiorella Iaquinta
Aquatic animals are capable of absorbing inorganic elements such as mercury (Hg) from soil, sediment and water, which is biomagnified, and due to human intake, it represents a potential risk of toxicity. Its presence is studied in foods of ...
A quantitative identification fluorescent probe for highly selective detection of Cu2+ in food and environmental samples [0.03%]
一种定量识别荧光探针用于食品和环境样品中Cu²⁺的高度选择性检测
Hui Xu,Jianing Zhang,Xiaomei Ren et al.
Hui Xu et al.
The potential accumulation of copper ions (Cu2+) in the food chain poses significant risks, making it imperative to develop efficient tools for real-time monitoring of Cu2+ levels in food, plants, and biological systems. In this study, two ...
M-Count: an application that uses machine learning object detection and color thresholding to count settled mussel larvae [0.03%]
基于机器学习对象检测和颜色阈值的着床贻贝幼虫计数应用M-Count
Lance W Miller,Navaj Nune,Thomas B LeFevre et al.
Lance W Miller et al.
Quantification of biofouling is a complex task that often involves counting both isolated and tightly packed groups of organisms on a test surface. Mussel larvae, which settle as both individuals and as clumps, are an important fouling orga...
Untargeted UHPLC-Q-Orbitrap metabolomics reveals hormonal suppression and candidate serum markers as evidence of testosterone misuse in cattle [0.03%]
基于UHPLC-Q-Orbitrap非目标代谢组学技术揭示睾酮在牛体内的抑制效应及候选标志物研究
Diego G Rocha,Mary A G Lana,Débora C S de Assis et al.
Diego G Rocha et al.
The illicit use of androgenic anabolic steroids, such as 17β-testosterone, in food-producing animals poses significant risks to animal welfare and consumer safety. Detecting exogenous administration of endogenous hormones like testosterone...
MALDI spatial proteomics: a mini review of approaches and techniques [0.03%]
基质辅助激光解析电离空间蛋白质组学：方法和技术简述
Arbil Lopez,Amanda B Hummon
Arbil Lopez
Spatial context is becoming increasingly important in the omics disciplines. Spatial proteomics is a diverse field encompassing numerous techniques that provide both the location and identity of proteins in biological samples. Improving upo...
Microalgae-derived quality control material for reproducible and scalable LC-MS system suitability testing [0.03%]
基于微藻的质量控制材料的LC-MS系统适用性测试的研究及应用
Wonseok Bang,Hyejeong Jung,Yejin Jeon et al.
Wonseok Bang et al.
Ensuring the accuracy and reliability of liquid chromatography-mass spectrometry (LC-MS/MS)-based proteomic analysis requires robust quality control (QC) strategies. However, widely used cell line-based QC materials present challenges in re...
Design and synthesis of a cobalt-doped carbon dot nanozyme for colorimetric/fluorometric dual-mode detection of nitrite ions and antibacterial applications [0.03%]
一种用于硝酸根阴离子和抗菌的类过氧化物酶碳点纳米酶的设计、合成及鉴定
Shansi Wei,Dai Li,Manqi Zang et al.
Shansi Wei et al.
In this work, novel cobalt-doped carbon dots (Co-CDs) were constructed via a facile single-step hydrothermal synthesis approach utilizing vitamin B12 (VB12) and L-tryptophan (L-Try) as precursors. Co-CDs illustrated exceptional peroxidase-l...
Cost-effective chloramphenicol residue monitoring in food-producing animal samples: a hybrid QuEChERS-MIP extraction method coupled with chrome azurol S spectrophotometry [0.03%]
一种用于食品动物样品中氯霉素残留检测的低成本方法：结合 azure A 染色的 hybrid QuEChERS-MIP 提取法及分光光度计测量法
Jalal N Jeber,Yasmeen H Muhamadali,Maher Ahmed Abed et al.
Jalal N Jeber et al.
Effective monitoring of chloramphenicol (CAP), a banned antibiotic in food-producing animals due to serious human health risks, demands highly sensitive and cost-efficient analytical methods suitable for complex matrices. This study present...