Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis [0.03%]
骨关节炎周围骨改变及软骨下骨与关节软骨相互作用机制研究进展
Steven R Goldring
Steven R Goldring
The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint. During the evolution of the osteoarthritic process biomechanical and biological processes ...
Biologicals and bone loss [0.03%]
生物制剂与骨丢失
Charlotte L M Krieckaert,Willem F Lems
Charlotte L M Krieckaert
Inflammatory joint diseases are associated with extra-articular side effects including bone involvement.There is an increased risk of osteoporotic fractures. The pathogeneses of local and generalized bone loss share a common pathway. Early ...
Assessment of synovitis to predict bone erosions in rheumatoid arthritis [0.03%]
评价滑膜炎来预测类风湿性关节炎患者的骨侵蚀情况
Serena Bugatti,Antonio Manzo,Roberto Caporali et al.
Serena Bugatti et al.
Although rheumatoid arthritis (RA) is traditionally considered as the prototype of destructive arthritis, the course of the disease varies considerably, with some patients experiencing more rapid progression of joint damage and disability t...
Piet Geusens
Piet Geusens
In the complex system of bone remodeling, the receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) pathway is the coupling factor between bone formation and bone resorption. RANKL binds to the RANK receptor of pre-o...
The role of biologic agents in damage progression in rheumatoid arthritis: indirect comparison of data coming from randomized clinical trials [0.03%]
生物制剂在类风湿性关节炎损害进展中的作用：来自随机临床试验的间接比较数据
Ennio Giulio Favalli,Francesca Pregnolato,Martina Biggioggero et al.
Ennio Giulio Favalli et al.
Objectives: All biologic agents approved for the treatment of rheumatoid arthritis (RA) have been tested versus methotrexate (MTX) for efficacy on damage progression in several randomized clinical trials (RCTs), but direc...
David M Reid
David M Reid
Efficacy, safety and mechanism of action of modified-release prednisone in rheumatoid arthritis [0.03%]
改良释药的泼尼松治疗类风湿性关节炎的疗效、安全性及作用机制
Lynsey Clarke,John Kirwan
Lynsey Clarke
Glucocorticoids (GCs) provide a powerful and widely used anti-inflammatory and disease-modifying therapy for rheumatoid arthritis (RA). However, concerns about adverse effects are driving efforts to find 'safer' GC or GC analogues. One nove...
Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties [0.03%]
结晶盐硫酸葡萄糖胺治疗膝关节炎的疗效、安全性及其药代动力学性质研究
Lucio C Rovati,Federica Girolami,Stefano Persiani
Lucio C Rovati
Glucosamine is an amino monosaccharide and a natural constituent of glycosaminoglycans in articular cartilage. When administered exogenously, it is used for the treatment of osteoarthritis as a prescription drug or a dietary supplement. The...
Management of radicular pain in rheumatic disease: insight for the physician [0.03%]
风湿病根性痛的治疗：给医师的观点和建议
Ade Adebajo,John Fabule
Ade Adebajo
Rheumatologists are still relatively unaware of the causes, presentation, diagnosis and management of radicular pain. This is against a background of increasing evidence of the presence and importance of radicular problems in patients with ...
Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity [0.03%]
心血管合并症患者的风湿性关节炎的甲氨蝶呤保护效应
Jonathan L Marks,Christopher J Edwards
Jonathan L Marks
Rheumatoid arthritis (RA) is associated with an increased risk of premature mortality, predominantly due to increased cardiovascular disease (CVD). Systemic inflammation has been established as one of the primary drivers of accelerated athe...