A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis [0.03%]
评估狄诺塞麦治疗绝经后妇女骨质疏松症有效性和安全性的系统评价和 meta 分析
Paul D Miller
Paul D Miller
Denosumab, a fully human monoclonal antibody to RANK ligand [RANK-L]) was approved for the treatment of postmenopausal osteoporosis in June 2010, and is highly effective in reducing the risk of vertebral, nonvertebral, and hip fracture risk...
Wen Xiong,Robert G Lahita
Wen Xiong
There are many new therapeutic directions for the disease systemic lupus erythematosus (SLE). Despite this, the US Food and Drug Administration (FDA) has approved only one biological agent and it involves B cells, now thought to play a sign...
Efficacy and safety of febuxostat in patients with hyperuricemia and gout [0.03%]
富马酸febuxostat片治疗高尿酸血症和痛风的疗效及安全性研究
Ignacio Garcia-Valladares,Tahir Khan,Luis R Espinoza
Ignacio Garcia-Valladares
The past decade has witnessed an exponential increase of novel therapeutic modalities for a variety of rheumatic disorders, including gout. During the past few years two novel therapeutic agents have been approved by the US Food and Drug Ad...
Christian Meier,Marius E Kraenzlin
Christian Meier
In recent years there has been increasing evidence suggesting that epilepsy and its treatment can have adverse effects on bone mineralization and calcium metabolism. Many studies have shown a significant reduction in bone mineral density (B...
Improved Sleep Efficiency after Anti-Tumor Necrosis Factor α Therapy in Rheumatoid Arthritis Patients [0.03%]
抗肿瘤坏死因子α治疗可改善类风湿关节炎患者的睡眠效率
Regina M Taylor-Gjevre,John A Gjevre,Bindu V Nair et al.
Regina M Taylor-Gjevre et al.
Background: Poor sleep health is increasingly recognized as contributing to decreased quality of life, increased morbidity/mortality and heightened pain perception. Our purpose in this study was to observe the effect on s...
Chad S Boomershine,Birol Emir,Yi Wang et al.
Chad S Boomershine et al.
Objectives: We tested the ability of the VASFIQ, a seven-item scale composed of Fibromyalgia Impact Questionnaire (FIQ) visual analog scales (VASs), to quantify fibromyalgia global disease severity and identify fibromyalg...
'Old drugs for new applications': can orthopedic research benefit from this strategy? [0.03%]
“老药新用”：骨科研究能否从中受益？
Xiaohua Pan,Wenxiang Cheng,Jiali Wang et al.
Xiaohua Pan et al.
New drug exploration is difficult in a clinical setting and the development of new drugs may be costly and time consuming. With further research into the pathological mechanisms and etiology of diseases as well as the rapid development of b...
Robert A Adler
Robert A Adler
Osteoporosis has finally been recognized as an important disorder in men. Men have osteoporotic fractures about 10 years later in life than women. Owing to increasing life expectancy, more fractures are predicted. Important risk factors for...
Management of chronic pain in the rheumatic diseases with insights for the clinician [0.03%]
风湿病慢性疼痛管理及临床意义
Mary-Ann Fitzcharles,Yoram Shir
Mary-Ann Fitzcharles
Pain that accompanies musculoskeletal conditions should be regarded as an illness entity in its own right and deserves treatment in parallel with the management of the underlying condition. Recent understanding of the pathophysiology of rhe...
Sodium oxybate: a potential new pharmacological option for the treatment of fibromyalgia syndrome [0.03%]
索拉氧贝：一种潜在的治疗纤维肌痛综合征的新药选择
Todd J Swick
Todd J Swick
Fibromyalgia syndrome (FMS) is a common disorder, characterized by diffuse pain and tenderness, stiffness, fatigue, affective disorders and significant sleep pathology. A new set of diagnostic criteria have been developed which should make ...