Domestic violence and chronic traumatic encephalopathy - an under-recognized link [0.03%]
家庭暴力与慢性创伤性脑病之间的联系不容忽视
María E Garay-Serratos
María E Garay-Serratos
Hans Christian Boesen,Ting Du,Steven A Goldman et al.
Hans Christian Boesen et al.
Delirium is a common and severe neuropsychiatric syndrome with lasting cognitive consequences, yet its pathophysiology remains poorly understood. We hypothesize that impaired glymphatic flow represents a central mechanism by which delirium ...
Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective [0.03%]
阿尔茨海默病的事件记忆维持与恢复：基于回路的观点
Emrah Düzel,Michael R Kreutz
Emrah Düzel
Losing track of personal experiences is a defining feature of Alzheimer disease (AD), arising from the spread of AD pathology through the brain circuits that support episodic memory. In this Review, we explore strategies to improve the func...
Heather Wood
Heather Wood
Tsunamis hiding in plain sight: spreading depression in clinical neurology [0.03%]
临床神经学中隐藏的海啸：弥漫性抑郁扩散机制在其中的作用
Cenk Ayata,Anders Hougaard,Steven J Schiff et al.
Cenk Ayata et al.
Spreading depression is a neurophysiological phenomenon that is observed in the central nervous system of many species, from insects to humans. In essence, spreading depression is a slowly propagating wave of mass depolarization (that is, s...
Modelling brain tumours with organoids: towards precision medicine in neuro-oncology [0.03%]
用类脑器官模拟脑肿瘤：神经肿瘤学的精准医疗研究方向
Marta de Lucas Sanz,Simone P Niclou,Anna Golebiewska
Marta de Lucas Sanz
Precision medicine in neuro-oncology hinges on our ability to decode the molecular and functional complexity of brain tumours. These tumours are highly heterogeneous and dynamic ecosystems that remain challenging to replicate with tradition...
Beth Grimsey
Beth Grimsey
Epidemiological principles behind worldwide growth of Parkinson disease - a bathtub analogy [0.03%]
帕金森病在全球增长背后的流行病学原理——浴缸类比法
Lisanne J Dommershuijsen,Sirwan K L Darweesh,Bastiaan R Bloem
Lisanne J Dommershuijsen
Eduardo Tolosa,Werner Poewe,Alastair J Noyce et al.
Eduardo Tolosa et al.
The current clinical diagnostic criteria for Parkinson disease (PD) have limitations and are inherently insensitive to the earliest stages of disease, when classical motor signs can be absent. Imaging and genetic tests are currently used to...