Müller cells and retinal axons can be primary targets in experimental neuromyelitis optica spectrum disorder [0.03%]
Müller细胞和视网膜轴突可以成为神经肌炎谱系疾病的主要靶点
Bleranda Zeka,Hans Lassmann,Monika Bradl
Bleranda Zeka
Recent work from our laboratory, using different models of experimental neuromyelitis optica spectrum disorder (NMOSD), has led to a number of observations that might be highly relevant for NMOSD patients. For example: (i) in the presence o...
Microglia communication: Parallels between aging and Alzheimer's disease [0.03%]
小胶质细胞通讯：衰老与阿尔茨海默病的相似性
Joe C Udeochu,Jeremy M Shea,Saul A Villeda
Joe C Udeochu
Aging alters the functional integrity of the adult brain, driving cognitive impairments and susceptibility to neurodegenerative disorders in healthy individuals. In fact, aging remains the most dominant risk factor for Alzheimer's disease (...
Patrick J Waters,Sean J Pittock,Jeffrey L Bennett et al.
Patrick J Waters et al.
Aquaporin-4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica-immunoglobulin G (NMO-IgG, or AQP4-Ig...
Current treatment status and medical cost for multiple sclerosis based on analysis of a Japanese claims database [0.03%]
基于日本理赔数据库的多发性硬化症当前治疗状况和医疗费用分析
Mieko Ogino,Izumi Kawachi,Kazuyoshi Otake et al.
Mieko Ogino et al.
Objective: To assist policymakers as they reflect on treatment protocols and approaches for the efficient delivery of medical care for multiple sclerosis (MS) patients in Japan. ...
Maureen A Mealy,Kyong Shin,Gareth John et al.
Maureen A Mealy et al.
Objectives: Neuromyelitis optica (NMO) is a relapsing autoimmune disease targeting the spinal cord and optic nerve leading to paralysis and blindness. Current treatment for acute NMO attacks is immunosuppression with high...
Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation [0.03%]
神经退行性疾病中的神经元-星形胶质细胞相互作用：神经炎症的作用
Kakulavarapu V Rama Rao,Tammy Kielian
Kakulavarapu V Rama Rao
Selective neuron loss in discrete brain regions is a hallmark of various neurodegenerative disorders, although the mechanisms responsible for this regional vulnerability of neurons remain largely unknown. Earlier studies attributed neuron d...
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination [0.03%]
中枢神经系统炎性脱髓鞘疾病免疫耐受机制研究进展
Elisabeth R Mari,Jason N Moore,Guang-Xian Zhang et al.
Elisabeth R Mari et al.
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system. Given that central nervous system infl...
Sergio E Baranzini
Sergio E Baranzini
Tob1 (transducer of ERBB2-1, TOB1 is humans) is a member of the antiproliferative (APRO) family of proteins that controls cell cycle progression in several cell types. In addition, Tob1 has been implicated in diverse cellular mechanisms suc...
Effects of prolonged treatment with memantine in the MRL model of CNS lupus [0.03%]
长效美金刚治疗MRL狼疮模型中枢神经系统损伤的作用及机制研究
Katarina Marcinko,Tiffany Parsons,Jason P Lerch et al.
Katarina Marcinko et al.
Objectives: Neuropsychiatric manifestations and brain atrophy of unknown etiology are common and severe complications of systemic lupus erythematosus (SLE). An autoantibody that binds to N-methyl-D-aspartate (NMDA) recept...