Mayssam A Nehme,Ashish Upadhyay
Mayssam A Nehme
Dyslipidemia is an established risk factor for cardiovascular disease. While statin therapy remains the most important component of dyslipidemia management, a substantial proportion of patients on statin monotherapy fails to achieve guideli...
A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism [0.03%]
左旋甲状腺素治疗甲状腺功能减退症的药代动力学综述
Philippe Colucci,Corinne Seng Yue,Murray Ducharme et al.
Philippe Colucci et al.
Thyroxine hormone has been recognised since the early part of the nineteenth century and levothyroxine has been available since the mid-nineteenth century as a replacement for deficient thyroid hormones. While levothyroxine remains the stap...
Short-term Withdrawal of Levothyroxine, Induced Increase of Thyroid-stimulating Hormone and an Increase Ratio of Triiodothyronine to Thyroxine [0.03%]
左旋甲状腺素短期撤药对促甲状腺激素、三碘甲状腺原氨酸/甲状腺素的影响
Martin Carlwe,Thomas Schaffer,Stefan Sjöberg
Martin Carlwe
Objective: Treatment with levothyroxine in primary hypothyroid patients does not always provide complete regression of associated symptoms despite normalised TSH levels. Several sources report ratios of triiodothyronine (T3) to thyroxine (T...
Iris Crespo,Alicia Santos,Eugenia Resmini et al.
Iris Crespo et al.
Evaluation of health-related quality of life (QoL) in people with pituitary tumours has received much attention over the last 10-15 years. Most of them show impaired QoL, but little is known about how to prevent impairment or how to improve...
Aneta L Zygulska,Krzysztof Krzemieniecki,Anna Sowa-Staszczak
Aneta L Zygulska
There are not effective therapies for metastatic unresectable, non-RAI-avid thyroid carcinomas. Fortunately, thyroid carcinomas represent a promising paradigm for targeted therapy due to the presence of activing mutations of genes coding th...
José Manuel Gómez-Sáez
José Manuel Gómez-Sáez
Thyroid nodules are a common clinical problem and evaluation with neck and thyroid ultrasound and fine-needle aspiration biopsy are the most accurate methods for evaluating and identifying those that require surgical resection. The surgical...
Hormone Therapy plus mTOR Inhibitors in the Treatment of Endometrial Carcinoma [0.03%]
激素治疗联合mTOR抑制剂在子宫内膜癌治疗中的应用
Erica M Stringer,Gini F Fleming
Erica M Stringer
Hormonal therapies such as progestins have only modest activity in the treatment of advanced endometrial cancer. Mechanisms of resistance to progestin therapy are not well understood. However, activation of the PI3K/AKT/mammalian target of ...
Sleeping Beauty or the Beast? - Metabolic Syndrome from an Obstructive Sleep Apnoea Perspective [0.03%]
从阻塞性睡眠呼吸暂停的角度看代谢综合征：睡美人还是怪物？
Lise Tarnow,Brigitte Klinkenbijl,Holger Woehrle
Lise Tarnow
Obstructive sleep apnoea (OSA) is a significant health issue. Patients with cardiovascular disease as well as patients with diabetes have a high prevalence of OSA, and the prevalence of coronary heart disease, heart failure, stroke and diab...
Giulio Frontino,Franco Meschi,Riccardo Bonfanti et al.
Giulio Frontino et al.
The prevalence of diabetes is increasing. improved glucose control is fundamental to reduce both long-term micro- and macrovascular complications and short-term complications, such as diabetic ketoacidosis and severe hypoglycemia. Frequent ...
Incidence of Hypoglycaemia in Patients with Type 2 Diabetes - A Subgroup Analysis from the GINGER study [0.03%]
Ginger研究中2型糖尿病患者的低血糖发生率——亚组分析
Andreas Fritsche,Almut Hahn,Wolfgang Landgraf et al.
Andreas Fritsche et al.
Introduction: The Glulisine in Combination with Insulin Glargine in an Intensified Insulin Regimen (GINGER) study compared insulin glargine plus insulin glulisine with premixed insulin in the treatment of patients with Type 2 diabetes melli...