Cardiorenal Syndrome in Type 2 Diabetes Mellitus - Rational Use of Sodium-glucose Cotransporter-2 Inhibitors [0.03%]
2型糖尿病中的心肾综合征与钠葡萄糖共转运体-2抑制剂的合理应用
Sanjay Kalra,Hasan Aydin,Manisha Sahay et al.
Sanjay Kalra et al.
Cardiorenal syndrome (CRS) in people with type 2 diabetes mellitus (T2DM) illustrates the bidirectional link between the heart and the kidneys, with acute or chronic dysfunction of one organ adversely impacting the function of the other. Of...
Short-term Hydroxychloroquine in COVID-19 Infection in People With or Without Metabolic Syndrome - Clearing Safety Issues and Good Clinical Practice [0.03%]
糖尿病或代谢综合征患者短期使用羟氯喹治疗新冠肺炎感染的安全性和良好临床实践
Deep Dutta,Meha Sharma,Rahul Sharma
Deep Dutta
Hydroxychloroquine has been used in rheumatology for decades. This review highlights the mechanistic, clinical and safety data with regards to hydroxychloroquine use in novel coronavirus disease (COVID-19) in people with or without metaboli...
Gagan Priya,Sarita Bajaj,Emmy Grewal et al.
Gagan Priya et al.
The coronavirus disease 2019 (COVID-19) pandemic has created significant challenges for healthcare systems across the world. The disease seems to infect men and women in equal numbers, though trends suggest that men have greater morbidity. ...
Sanjay Kalra,Om J Lakhani,Sandeep Chaudhary
Sanjay Kalra
Takotsubo cardiomyopathy (TCMP) is a cardiac disorder, often seen in post-menopausal women, that resembles an acute coronary syndrome in its clinical presentation. The aetiopathogenesis of TCMP may have an endocrine basis, and hence we beli...
High-dose Somatostatin Analogues for Progressive Neuroendocrine Tumours [0.03%]
高剂量生长抑素类似物对进展性神经内分泌肿瘤的作用
Anna J Sharp,Aimee R Hayes,Ashley Grossman
Anna J Sharp
Neuroendocrine tumours are a heterogeneous group of neoplasms with a variety of treatment options, but studies suggest they should in most cases, if they are not curable surgically, be treated initially with monthly long-acting somatostatin...
Sanjay Kalra,Saptarshi Bhattacharya,Atul Kalhan
Sanjay Kalra
The evidence derived from observational studies suggests male gender, diabetes and central obesity to be risk factors associated with an increased COVID-19-related case fatality. The precise pathophysiology behind this gender difference in ...
John Doupis,Konstantinos Avramidis
John Doupis
The coronavirus disease 2019 (COVID-19) pandemic has affected almost every country in the world and has changed the way we access healthcare. People with pre-existing conditions, such as diabetes, are at high risk of a severe disease course...
Pheochromocytoma Due to TMEM127 Mutation - The Importance of Genetic Testing for Clinical Decision [0.03%]
TMEM127基因突变引起的嗜铬细胞瘤——遗传检测在临床决策中的重要性
Sílvia Cristina de Sousa Paredes,Sara Gomes de Campos Lopes,Isabel Maria Beleza Ferraz Torres et al.
Sílvia Cristina de Sousa Paredes et al.
Apreviously healthy 53-year-old woman presented with new onset arterial hypertension diagnosed during workup for daily pulsatile bilateral frontal headaches and paroxysmal episodes of fatigue, palpitations and sweating. High urinary metanep...
Matteo Parolin,Francesca Dassie,Eugenio De Carlo et al.
Matteo Parolin et al.
We briefly describe a case of a 31-year-old man with persistent hyperthyroidism, despite medical treatment with high dose methimazole. Twelve-lead 24-hour Holter monitoring showed bifid (or dome-and-dart) T waves and echocardiography reveal...
Hyperinsulinaemic Hypoglycaemia and Polycystic Kidney Disease - A Rare Case Concerning PMM2 Gene Pleiotropy [0.03%]
与PMM2基因多效性相关的肝外胰岛素瘤和多囊肾病罕见病例报告
Ana Rita Soares,Catarina Matos Figueiredo,Dulce Quelhas et al.
Ana Rita Soares et al.
Co-occurrence of hyperinsulinaemic hypoglycaemia and polycystic kidney disease (HIPKD) has been recently described. It is caused by a non-coding variant in the promoter region for phosphomannomutase 2 (PMM2), c.-167G>T, both in homozygous o...