Flaviano Giorgini
Flaviano Giorgini
IPX066: a new intermediate-and extended-release carbidopa-levodopa formulation [0.03%]
_ipx066：一种新的中间及长效卡比多巴-左旋多巴剂型_
Talene A Yacoubian
Talene A Yacoubian
Carbidopa-levodopa (CD-LD) is the mainstay of treatment for Parkinson's disease (PD), yet most patients with advanced PD develop motor fluctuations with time when treated with CD-LD. Development of longer-acting CD-LD formulations is a majo...
Oliver W J Quarrell,Martha A Nance,Peggy Nopoulos et al.
Oliver W J Quarrell et al.
Huntington's disease (HD) is a well-recognized progressive neurodegenerative disorder that follows an autosomal dominant pattern of inheritance. Onset is insidious and can occur at almost any age, but most commonly the diagnosis is made bet...
Neuropsychiatric symptoms in primary progressive aphasia: phenomenology, pathophysiology, and approach to assessment and treatment [0.03%]
原发性进行性失语的神经精神症状：临床特征、病理生理及评估和治疗概述
Mandana Modirrousta,Bruce H Price,Bradford C Dickerson
Mandana Modirrousta
Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious and progressive loss of language. Current diagnostic criteria require symptoms to be largely restricted to language dysfunction for at least the fi...
The role of exercise in facilitating basal ganglia function in Parkinson's disease [0.03%]
运动在帕金森病基底节功能中的作用
Giselle M Petzinger,Beth E Fisher,Garnik Akopian et al.
Giselle M Petzinger et al.
Epidemiological and clinical studies have suggested that exercise is beneficial for patients with Parkinson's disease (PD). Through research in normal (noninjured) animals, neuroscientists have begun to understand the mechanisms in the brai...
Impulse control disorders in Parkinson's disease: background and update on prevention and management [0.03%]
帕金森病的冲动控制障碍：背景及预防和管理的更新
Robert F Leeman,Benjamin E Billingsley,Marc N Potenza
Robert F Leeman
Given that impulse control disorders (ICDs) have been identified among a considerable minority of Parkinson's disease (PD) patients, these conditions have gained increased clinical and research attention in the past decade. Dopamine-replace...
Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease? [0.03%]
日常生活活动：阿尔茨海默病诊断中的地位如何？
Gad A Marshall,Rebecca E Amariglio,Reisa A Sperling et al.
Gad A Marshall et al.
Impairment in activities of daily living (ADL) accompanies cognitive and behavioral symptoms in Alzheimer's disease (AD). Conventionally, ADL impairment has been relegated to the stage of dementia, but instrumental ADL impairment has been s...
Therapeutic potential of targeting metabotropic glutamate receptors for Parkinson's disease [0.03%]
靶向代谢型谷氨酸受体治疗帕金森病的潜在作用
Jonathan W Dickerson,P Jeffrey Conn
Jonathan W Dickerson
Parkinson's disease (PD) is a progressive neurological disorder predominantly characterized by motor symptoms including bradykinesia and resting tremor. The gold standard of treatment for PD remains dopamine replacement therapy, which event...
How predictive of dementia are peripheral inflammatory markers in the elderly? [0.03%]
外周炎症标志物对老年痴呆的预测作用有多大？
Andrea L Metti,Jane A Cauley
Andrea L Metti
Dementia is a huge public health concern today owing to the exponentially increasing number of older adults it affects each year, and there has been a large number of investigators looking at potential biomarkers of dementia. Peripheral inf...