Could the detection of visual disturbances associated with Parkinson's disease genes in flies lead to new treatments for the disease? [0.03%]
果蝇视觉异常检测或为帕金森病基因治疗提供新途径
Alex R Wade,Christopher J H Elliott
Alex R Wade
Should we disclose amyloid imaging results to cognitively normal individuals? [0.03%]
我们应该向认知正常的个体披露淀粉样蛋白成像结果吗？
Joshua D Grill,David K Johnson,Jeffrey M Burns
Joshua D Grill
Demonstration of brain accumulation of fibrillar amyloid beta protein via positron emission tomography (PET) with amyloid specific ligands may support the diagnosis of Alzheimer's disease (AD). There is increasing recognition of the potenti...
Julia J Hsiao,Edmond Teng
Julia J Hsiao
The updated diagnostic criteria for Alzheimer's disease (AD) distinguish three stages: dementia, symptomatic pre-dementia [i.e. mild cognitive impairment (MCI)], and asymptomatic pre-dementia. Although AD is primarily associated with cognit...
Current guidelines for dementia screening: shortcomings and recommended changes [0.03%]
痴呆筛查现行指南的不足与推荐改进措施
Magdalena I Tolea,James E Galvin
Magdalena I Tolea
The availability of various guidelines regarding the diagnosis of Alzheimer's disease (AD) leaves most primary care providers with the task of having to decide which guidelines to follow. This review will help them navigate these different ...
Roland Dominic G Jamora,Lourdes K Ledesma,Aloysius Domingo et al.
Roland Dominic G Jamora et al.
The natural history of sex-linked dystonia parkinsonism (XDP) has been well documented. However, its nonmotor features have not yet been fully described. We reviewed the available literature on the nonmotor features in XDP. We found five ar...
Clinical insights into use of apomorphine in Parkinson's disease: tools for clinicians [0.03%]
透析临床医生对帕金森病使用阿朴吗啡的见解：临床工具
Tove Henriksen
Tove Henriksen
Apomorphine was introduced before the era of levodopa as a treatment for idiopathic Parkinson's disease (iPD). A number of practical obstacles were to be solved before a wider use of the drug was possible. Today, however, the drug is probab...
Alzheimer's disease and vascular dementia: one potentially preventable and modifiable disease? Part II: Management, prevention and future perspective [0.03%]
阿尔茨海默病和血管性痴呆：一种可能可预防和可以改变的疾病？第二部分：管理、预防和未来前景
Dennis A Davey
Dennis A Davey
The management of dementia and mild cognitive impairment (MCI) includes pharmacological, nonpharmacological and caregiver interventions. Acetyl-cholinesterase inhibitors and memantine have a small beneficial effect in mild-to-moderate demen...
Alzheimer's disease and vascular dementia: one potentially preventable and modifiable disease. Part I: Pathology, diagnosis and screening [0.03%]
阿尔茨海默病与血管性痴呆：可预防和干预的疾病。第一部分：病理、诊断与筛查
Dennis A Davey
Dennis A Davey
Alzheimer's disease (AD) and vascular dementia (VaD) frequently coexist and their separation may well be a false dichotomy. The neurodegenerative and cerebrovascular changes vary from the extremes of 'pure AD' to 'pure VaD' and a combinatio...
Mohammad H Dehabadi,Benjamin M Davis,Timothy K Wong et al.
Mohammad H Dehabadi et al.
Alzheimer's disease (AD) is neurodegenerative condition and most common cause of dementia worldwide. Current criteria for its diagnosis and monitoring rely on subjective, expensive or invasive methods that lack sufficient sensitivity, such ...
The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis [0.03%]
少突胶质细胞功能障碍在肌萎缩侧索硬化症中的作用
Annelies Nonneman,Wim Robberecht,Ludo Van Den Bosch
Annelies Nonneman
Healthy oligodendrocytes are crucial for neurons and abnormal functioning of these cells is involved in several neurodegenerative diseases. We will focus on oligodendroglial pathology in amyotrophic lateral sclerosis (ALS), an adult-onset p...