Jessica Cooperrider,Jeffrey Lambe,Michelle Chu et al.
Jessica Cooperrider et al.
Aim: Ozanimod is a second-generation sphingosine 1-phosphate receptor (S1PR) modulator approved for treatment of relapsing multiple sclerosis (MS). Data are lacking for ozanimod use in real-world clinical practice. This s...
Pain and fatigue in amyotrophic lateral sclerosis: a multiple methods study [0.03%]
渐冻症患者的疼痛与疲劳感：一项多层次研究
Stephano Tomaz Silva,Letícia Maria de Queiroz Aquino,Diogo Neres Aires et al.
Stephano Tomaz Silva et al.
Introduction: Pain and fatigue are frequent symptoms in individuals with Amyotrophic Lateral Sclerosis (ALS) and the literature is controversial regarding the effectiveness of physiotherapy practices for managing these sy...
Emerging Alzheimer's therapies: clinical efficacy versus economic feasibility [0.03%]
新兴阿尔茨海默症疗法：临床有效性和经济可行性之间的权衡取舍问题
Natalia Shahid,Laiba Azhar,Ishtiaq Hussain et al.
Natalia Shahid et al.
Multiple sclerosis expert patient program in Central America: changes in quality of life and lifestyle habits [0.03%]
中美洲多发性硬化患者教育项目对改善患者生活质量及生活方式的改变的影响
Emilia Arrighi,Carlos Navas,Natalia Vázquez et al.
Emilia Arrighi et al.
Aims: To assess the impact of an Expert Patient Program on the quality of life and lifestyle habits of multiple sclerosis patients and their caregivers from Costa Rica, Honduras, and Dominican Republic. ...
The impact of non-motor symptoms on physical activity in Parkinson's disease [0.03%]
帕金森病非运动症状对体力活动的影响
Sarah J Conklin,Leah Vaikutis,Travis Loux et al.
Sarah J Conklin et al.
Aims: To examine how specific non-motor symptoms (NMS) are associated with physical activity engagement in individuals with Parkinson's disease (PD). Mate...
Neuropathology of Friedreich ataxia and its links to metabolic pathways [0.03%]
弗里德赖希共济失调的神经病理与代谢途径之间的联系
Elizabeth Mercado-Ayón,Michael P Lazaropoulos,Yesica Mercado-Ayón et al.
Elizabeth Mercado-Ayón et al.
Frataxin is an evolutionarily conserved mitochondrial protein essential for energy metabolism. Biallelic GAA repeat expansions in the FXN gene reduce frataxin expression, causing Friedreich's ataxia. Frataxin deficiency impairs key mitochon...
Amantadine for multiple sclerosis-related fatigue: a systematic review and meta-analysis of randomized controlled trials [0.03%]
氨甲环酸治疗多发性硬化相关疲劳：随机对照试验的系统评价和.meta.分析
Murilo Marmori Cruccioli,Pedro Henrique Teixeira Carneiro,Jorge Ferreira Jasmineiro Pitanga et al.
Murilo Marmori Cruccioli et al.
Background: Fatigue affects up to 95% of individuals with multiple sclerosis (MS), significantly impairing daily functioning. Management is multidisciplinary, and although amantadine lacks U.S. FDA approval for this indic...
Trends in motor neuron disease mortality in the United States from 1999 to 2020 [0.03%]
美国1999至2020年运动神经元疾病死亡率变化趋势
Yue-Feng Li,Yun-Fei Zheng
Yue-Feng Li
Background: Motor neuron disease (MND) is a rare, fatal neurodegenerative disorder associated with high mortality and disability, posing a significant healthcare burden. This study analyzed the United States mortality tre...
Real-world analysis of medication adherence and cost of care for comorbid conditions in patients with early Alzheimer's disease in the U.S [0.03%]
美国阿尔茨海默病患者共病的现实世界分析及依从性与医疗费用的关系
Lei Lv,Abdalla Aly,Caroline McKay et al.
Lei Lv et al.
Aim: To understand medication adherence and associated healthcare costs of patients with early Alzheimer's disease (AD). Methods: This ...
Tetramethylpyrazine nitrone: a multifaceted neuroprotective agent in neurodegenerative disorders [0.03%]
四甲基吡嗪亚硝基：神经退行性疾病的多功能神经保护剂
Eshak I Bahbah
Eshak I Bahbah
Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) share key pathological features, including oxidative stress, mitochondrial dysfunction, and impaired protein hom...