Chuan Hock Koh,Sharene Lin,Gregory Jedd et al.
Chuan Hock Koh et al.
Computational tools are essential components of modern biological research. For example, BLAST searches can be used to identify related proteins based on sequence homology, or when a new genome is sequenced, prediction models can be used to...
A probabilistic framework to improve microrna target prediction by incorporating proteomics data [0.03%]
一种通过整合蛋白质组数据改进微小核糖核酸靶点预测的概率模型框架
Jingjing Li,Renqiang Min,Anthony Bonner et al.
Jingjing Li et al.
Due to the difficulties in identifying microRNA (miRNA) targets experimentally in a high-throughput manner, several computational approaches have been proposed. To this date, most leading algorithms are based on sequence information alone. ...
Dimension reduction of microarray gene expression data: the accelerated failure time model [0.03%]
微阵列基因表达数据的降维：加速失效时间模型
Tuan S Nguyen,Javier Rojo
Tuan S Nguyen
The construction of the components of Partial Least Squares (PLS) is based on the maximization of the covariance/correlation between linear combinations of the predictors and the response. However, the usual Pearson correlation is influence...
On the asymmetry of the residue compositions of the binding sites on protein surfaces [0.03%]
蛋白质表面结合位点残基组成的不对称性
Gábor Iván,Zoltán Szabadka,Vince Grolmusz
Gábor Iván
By screening all the ligand binding sites in the Protein Data Bank, we have found that while it is geometrically possible that a loop, formed from a protein chain with residues ZYX, would "impersonate" another chain-loop with residues XYZ b...
Analysis of mesenchymal stem cell differentiation in vitro using classification association rule mining [0.03%]
基于分类关联规则挖掘的体外间充质干细胞分化分析
Weiqi Wang,Yanbo Justin Wang,René Bañares-Alcántara et al.
Weiqi Wang et al.
In this paper, data mining is used to analyze the data on the differentiation of mammalian Mesenchymal Stem Cells (MSCs), aiming at discovering known and hidden rules governing MSC differentiation, following the establishment of a web-based...