Is LGI2 the candidate gene for partial epilepsy with pericentral spikes? [0.03%]
LGI2是半侧自主性中央区尖波癫痫的候选基因吗？
Vachiranee Limviphuvadh,Ling Ling Chua,Frank Eisenhaber et al.
Vachiranee Limviphuvadh et al.
Partial epilepsy with pericentral spikes (PEPS) is a familial epilepsy with disease locus mapped to human chromosome region 4p15; yet, the causative gene is unknown. In this work, arguments based on protein sequence analysis and patient-spe...
Jiyuan An,Kwok Pui Choi,Christine A Wells et al.
Jiyuan An et al.
Background: Current miRNA target prediction tools have the common problem that their false positive rate is high. This renders identification of co-regulating groups of miRNAs and target genes unreliable. In this study, w...
Guozhu Dong,Lei Duan,Changjie Tang
Guozhu Dong
In applications such as gene therapy and drug design, a key goal is to convert the disease state of diseased objects from an undesirable state into a desirable one. Such conversions may be achieved by changing the values of some attributes ...
A quantum-inspired genetic algorithm based on probabilistic coding for multiple sequence alignment [0.03%]
一种基于概率编码的量子遗传算法在多序列比对中的应用研究
Hong-Wei Huo,Vojislav Stojkovic,Qiao-Luan Xie
Hong-Wei Huo
Quantum parallelism arises from the ability of a quantum memory register to exist in a superposition of base states. Since the number of possible base states is 2(n), where n is the number of qubits in the quantum memory register, one opera...
Rezwan Ahmed,Huzefa Rangwala,George Karypis
Rezwan Ahmed
Alpha-helical transmembrane proteins mediate many key biological processes and represent 20%-30% of all genes in many organisms. Due to the difficulties in experimentally determining their high-resolution 3D structure, computational methods...
A multi-strategy approach to informative gene identification from gene expression data [0.03%]
基于基因表达数据的多策略信息基因识别方法
Ziying Liu,Sieu Phan,Fazel Famili et al.
Ziying Liu et al.
An unsupervised multi-strategy approach has been developed to identify informative genes from high throughput genomic data. Several statistical methods have been used in the field to identify differentially expressed genes. Since different ...
Temperature-dependent structural variability of RNAs: spliced leader RNAs and their evolutionary history [0.03%]
温度依赖性的RNA结构多变性：转移RNA前体及其进化历史
Manja Marz,Nathalie Vanzo,Peter F Stadler
Manja Marz
The structures attained by RNA molecules depend not only on their sequence but also on environmental parameters such as their temperature. So far, this effect has been largely neglected in bioinformatics studies. Here, we show that structur...
Exploring the protein landscape in ramachandran space: it's not just psi-phi [0.03%]
探索rama空间中的蛋白质景观：不仅仅是psi-phi角度
William Krivan,Darrick Carter
William Krivan
Most methods for the structural comparison of proteins utilize molecular coordinates in the three-dimensional physical space. Recently, a group has presented an elegant novel approach based on the characterization of protein shape in terms ...
Inference of gene regulatory networks using boolean-network inference methods [0.03%]
基于布尔网络推理方法的基因调控网络推断研究进展
Graham J Hickman,T Charlie Hodgman
Graham J Hickman
The modeling of genetic networks especially from microarray and related data has become an important aspect of the biosciences. This review takes a fresh look at a specific family of models used for constructing genetic networks, the so-cal...
In silico screening of protein-protein interactions with all-to-all rigid docking and clustering: an application to pathway analysis [0.03%]
基于刚性对接和聚类的全对全蛋白质-蛋白质相互作用的计算机虚拟筛选及其在通路分析中的应用
Yuri Matsuzaki,Yusuke Matsuzaki,Toshiyuki Sato et al.
Yuri Matsuzaki et al.
We propose a computational screening system of protein-protein interactions using tertiary structure data. Our system combines all-to-all protein docking and clustering to find interacting protein pairs. We tuned our prediction system by ap...