Tomoko Ohta,Sampo Pyysalo,Jin-Dong Kim et al.
Tomoko Ohta et al.
Text mining can support the interpretation of the enormous quantity of textual data produced in biomedical field. Recent developments in biomedical text mining include advances in the reliability of the recognition of named entities (NEs) s...
Yue Wang,Jin-Dong Kim,Rune Saetre et al.
Yue Wang et al.
Although there are several corpora with protein annotation, incompatibility between the annotations in different corpora remains a problem that hinders the progress of automatic recognition of protein names in biomedical literature. Here, w...
Analysis of qPCR data by converting exponentially related Ct values into linearly related X0 values [0.03%]
通过将指数相关的Ct值转换为线性相关的X0值进行qPCR数据的分析
Rune Thomsen,Christina Ane Elisabeth Sølvsten,Toke Elbek Linnet et al.
Rune Thomsen et al.
A common method for calculating results from qPCR experiments is the comparative Ct method, also called the 2(-ΔΔCt) method. However, several assumptions are included in the 2(-ΔΔCt) method and standard statistical analyses are not dire...
Yuzhong Zhao,Babak Alipanahi,Shuai Cheng Li et al.
Yuzhong Zhao et al.
Accurate determination of protein secondary structure from the chemical shift information is a key step for NMR tertiary structure determination. Relatively few work has been done on this subject. There needs to be a systematic investigatio...
Computational gene knockout reveals transdisease-transgene association structure [0.03%]
计算基因剔除揭示了跨疾病-跨基因关联结构
Tsutomu Matsunaga,Shuhei Kuwata,Masaaki Muramatsu
Tsutomu Matsunaga
Genome-wide association studies for a variety of diseases are identifying increasing numbers of candidate genes. Now we are confronted with the fact that some genes are common candidates across diseases. Thus there is a strong need to devel...
Ulavappa B Angadi,M Venkatesulu
Ulavappa B Angadi
One of the major research directions in bioinformatics is that of predicting the protein superfamily in large databases and classifying a given set of protein domains into superfamilies. The classification reflects the structural, evolution...
Relative von Neumann entropy for evaluating amino acid conservation [0.03%]
相对von neumann熵在氨基酸保守性评价中的应用
Fredrik Johansson,Hiroyuki Toh
Fredrik Johansson
The Shannon entropy is a common way of measuring conservation of sites in multiple sequence alignments, and has also been extended with the relative Shannon entropy to account for background frequencies. The von Neumann entropy is another e...
A graph-based algorithm for mining multi-level patterns in genomic data [0.03%]
一种在基因组数据中挖掘多层次模式的图算法
Winnie W M Lam,Keith C C Chan,David K Y Chiu et al.
Winnie W M Lam et al.
Comparative genomics is concerned with the study of genome structure and function of different species. It can provide useful information for the derivation of evolutionary and functional relationships between genomes. Previous work on geno...