Expansin gene family database: A comprehensive bioinformatics resource for plant expansin multigene family [0.03%]
植物EXPANSIN多基因家族的生物信息学数据库
Büşra Özkan Kök,Yasemin Celik Altunoglu,Ali Burak Öncül et al.
Büşra Özkan Kök et al.
Expansins, which are plant cell wall loosening proteins associated with cell growth, have been identified as a multigene family. Plant expansin proteins are an important family that functions in cell growth and many of developmental process...
Overlapping group screening for binary cancer classification with TCGA high-dimensional genomic data [0.03%]
基于TCGA高维基因组数据的二元癌症分类重叠组筛选方法研究
Jie-Huei Wang,Yi-Hau Chen
Jie-Huei Wang
Precision medicine has been a global trend of medical development, wherein cancer diagnosis plays an important role. With accurate diagnosis of cancer, we can provide patients with appropriate medical treatments for improving patients' surv...
Pooja Rani,Kamlesh Dutta,Vijay Kumar
Pooja Rani
Drug synergy has emerged as a viable treatment option for malignancy. Drug synergy reduces toxicity, improves therapeutic efficacy, and overcomes drug resistance when compared to single-drug doses. Thus, it has attained significant interest...
Identification of a seven autophagy-related gene pairs signature for the diagnosis of colorectal cancer using the RankComp algorithm [0.03%]
基于RankComp算法鉴定七个自噬相关基因对联合诊断结直肠癌的标志物
Qi-Shi Song,Hai-Jun Wu,Qian Lin et al.
Qi-Shi Song et al.
Based on the colorectal cancer microarray sets gene expression data series (GSE) GSE10972 and GSE74602 in colon cancer and 222 autophagy-related genes, the differential signature in colorectal cancer and paracancerous tissues was analyzed b...
Integrating temporal and spatial variabilities for identifying ion binding proteins in phage [0.03%]
结合时间和空间变化以识别噬菌体中的离子结合蛋白
Hongliang Zou,Zizheng Yu,Zhijian Yin
Hongliang Zou
Recent studies reported that ion binding proteins (IBPs) in phage play a key role in developing drugs to treat diseases caused by drug-resistant bacteria. Therefore, correct recognition of IBPs is an urgent task, which is beneficial for und...
The mechanism accounting for DNA damage strength modulation of p53 dynamical properties [0.03%]
调控DNA损伤强度的p53动力学性质机制研究
Aiqing Ma,Xianhua Dai
Aiqing Ma
The P53 protein levels exhibit a series of pulses in response to DNA double-stranded breaks (DSBs). However, the mechanism regarding how damage strength regulates physical parameters of p53 pulses remains to be elucidated. This paper establ...
Antimicrobial peptides recognition using weighted physicochemical property encoding [0.03%]
基于加权物理化学性质编码的抗菌肽识别模型
Standa Na,Dhammika Leshan Wannigama,Thammakorn Saethang
Standa Na
Antimicrobial resistance is a major public health concern. Antimicrobial peptides (AMPs) are one of the host defense mechanisms responding efficiently against multidrug-resistant microbes. Since the process of screening AMPs from a large nu...
Rearrangement distance with reversals, indels, and moves in intergenic regions on signed and unsigned permutations [0.03%]
带符号和无符号排列的逆转、插入删除和滑动的排序问题的距离算法研究
Klairton Lima Brito,Andre Rodrigues Oliveira,Alexsandro Oliveira Alexandrino et al.
Klairton Lima Brito et al.
Genome rearrangement events are widely used to estimate a minimum-size sequence of mutations capable of transforming a genome into another. The length of this sequence is called distance, and determining it is the main goal in genome rearra...
Integrated in silico- in vitro rational design of oncogenic EGFR-derived specific monoclonal antibody-binding peptide mimotopes [0.03%]
基于计算与实验的致癌EGFR衍生特异性单克隆抗体结合肽模仿体的理性设计
Ke Chen,Lili Ge,Guorui Liu
Ke Chen
Human epidermal growth factor receptor (EGFR) is strongly associated with malignant proliferation and has been established as an attractive therapeutic target of diverse cancers and used as a significant biomarker for tumor diagnosis. Over ...
ThermalProGAN: A sequence-based thermally stable protein generator trained using unpaired data [0.03%]
基于序列的热稳定蛋白质生成器ThermalProGAN：使用未配对数据训练模型
Hui-Ling Huang,Chong-Heng Weng,Torbjörn E M Nordling et al.
Hui-Ling Huang et al.
Motivation: The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted by s...