Inferring haplotypes from genotypes on a pedigree with mutations, genotyping errors and missing alleles [0.03%]
含突变、基因型错误及等位基因缺失的谱系的基因组 Pharao 算法及其应用研究
Wei-Bung Wang,Tao Jiang
Wei-Bung Wang
Inferring the haplotypes of the members of a pedigree from their genotypes has been extensively studied. However, most studies do not consider genotyping errors and de novo mutations. In this paper, we study how to infer haplotypes from gen...
ncRNA consensus secondary structure derivation using grammar strings [0.03%]
基于文法串的非编码RNA一致二级结构预测方法研究
Rujira Achawanantakun,Yanni Sun,Seyedeh Shohreh Takyar
Rujira Achawanantakun
Many noncoding RNAs (ncRNAs) function through both their sequences and secondary structures. Thus, secondary structure derivation is an important issue in today's RNA research. The state-of-the-art structure annotation tools are based on co...
Lex-SVM: exploring the potential of exon expression profiling for disease classification [0.03%]
基于内含子表达谱的疾病分类的潜力研究_lex-svm算法
Xiongying Yuan,Yi Zhao,Changning Liu et al.
Xiongying Yuan et al.
Exon expression profiling technologies, including exon arrays and RNA-Seq, measure the abundance of every exon in a gene. Compared with gene expression profiling technologies like 3' array, exon expression profiling technologies could detec...
Analyzing modular RNA structure reveals low global structural entropy in microRNA sequence [0.03%]
模块化RNA结构分析揭示了microRNA序列中的低全局结构熵
Timothy I Shaw,Amir Manzour,Yingfeng Wang et al.
Timothy I Shaw et al.
Secondary structure remains the most exploitable feature for noncoding RNA (ncRNA) gene finding in genomes. However, methods based on secondary structure prediction may generate superfluous amount of candidates for validation and have yet t...
Hatice Gulcin Ozer,Yi-Wen Huang,Jiejun Wu et al.
Hatice Gulcin Ozer et al.
New high-throughput sequencing technologies can generate millions of short sequences in a single experiment. As the size of the data increases, comparison of multiple experiments on different cell lines under different experimental conditio...
Classification of large microarray datasets using fast random forest construction [0.03%]
利用快速随机森林构建方法分类大规模微阵列数据
Elena A Manilich,Z Meral Özsoyoğlu,Valeriy Trubachev et al.
Elena A Manilich et al.
Random forest is an ensemble classification algorithm. It performs well when most predictive variables are noisy and can be used when the number of variables is much larger than the number of observations. The use of bootstrap samples and r...
Temporal graphical models for cross-species gene regulatory network discovery [0.03%]
跨物种基因调控网络发现的时序图模型
Yan Liu,Alexandru Niculescu-Mizil,Aurélie Lozano et al.
Yan Liu et al.
Many genes and biological processes function in similar ways across different species. Cross-species gene expression analysis, as a powerful tool to characterize the dynamical properties of the cell, has found a number of applications, such...
Optimization of therapeutic proteins to delete T-cell epitopes while maintaining beneficial residue interactions [0.03%]
优化治疗蛋白以删除T细胞表位同时保持有益的残基相互作用
Andrew S Parker,Karl E Griswold,Chris Bailey-Kellogg
Andrew S Parker
Exogenous enzymes, signaling peptides, and other classes of nonhuman proteins represent a potentially massive but largely untapped pool of biotherapeutic agents. Adapting a foreign protein for therapeutic use poses numerous design challenge...