The use of 4D data-independent acquisition-based proteomic analysis and machine learning to reveal potential biomarkers for stress levels [0.03%]
基于4D数据非独立获取的蛋白质组分析和机器学习揭示压力水平潜在生物标志物的研究
Dehua Chen,Yongsheng Yang,Dongdong Shi et al.
Dehua Chen et al.
Research suggests that individuals who experience prolonged exposure to stress may be at higher risk for developing psychological stress disorders. Currently, psychological stress is primarily evaluated by professional physicians using rati...
Analyzing the performance of short-read classification tools on metagenomic samples toward proper diagnosis of diseases [0.03%]
分析短读长分类工具在元基因组样本中的性能以正确诊断疾病
Leili Irankhah,Babak Khorsand,Mahmoud Naghibzadeh et al.
Leili Irankhah et al.
Accurate knowledge of the genome, virus and bacteria that have invaded our bodies is crucial for diagnosing many human diseases. The field of bioinformatics encompasses the complex computational methods required for this purpose. Metagenomi...
Polypharmacy side effect prediction based on semi-implicit graph variational auto-encoder [0.03%]
基于半隐式图变自动编码器的多药副作用预测
Zhou Yi,Minzhu Xie
Zhou Yi
Polypharmacy, the use of drug combinations, is an effective approach for treating complex diseases, but it increases the risk of adverse effects. To predict novel polypharmacy side effects based on known ones, many computational methods hav...
CW-PRED: Prediction of C-terminal surface anchoring sorting signals in bacteria and Archaea [0.03%]
细菌和古菌C端表面锚定分拣信号的预测(CW-PRED)
Aikaterini G Chatziargyri,Evangelia A Stasi,Konstantinos I Tsirigos et al.
Aikaterini G Chatziargyri et al.
Sorting signals are crucial for the anchoring of proteins to the cell surface in archaea and bacteria. These proteins often feature distinct motifs at their C-terminus, cleaved by sortase or sortase-like enzymes. Gram-positive bacteria exhi...
An ensemble approach for circular RNA-disease association prediction using variational autoencoder and genetic algorithm [0.03%]
基于变分自动编码器和遗传算法的圆形单链RNA-疾病关联预测集成方法
C M Salooja,Arjun Sanker,K Deepthi et al.
C M Salooja et al.
Circular RNAs (circRNAs) are endogenous non-coding RNAs with a covalently closed loop structure. They have many biological functions, mainly regulatory ones. They have been proven to modulate protein-coding genes in the human genome. CircRN...
Jia Gao,Yun Xu
Jia Gao
The graph of sequences represents the genetic variations of pan-genome concisely and space-efficiently than multiple linear reference genome. In order to accelerate aligning reads to the graph, an index of graph-based reference genomes is u...
Andrejs Sizovs,Gatis Melkus,Peteris Rucevskis et al.
Andrejs Sizovs et al.
Chromatin interaction data are frequently analyzed as a network to study several aspects of chromatin structure. Hi-C experiments are costly and there is a need to create simulated networks for quality assessment or result validation purpos...
PCA-constrained multi-core matrix fusion network: A novel approach for cancer subtype identification [0.03%]
一种新颖的癌症亚型识别方法：受PCA约束的多核矩阵融合网络
Min Li,Zhifang Qi,Liang Liu et al.
Min Li et al.
Cancer subtyping refers to categorizing a particular cancer type into distinct subtypes or subgroups based on a range of molecular characteristics, clinical manifestations, histological features, and other relevant factors. The identificati...
Integration of autoencoder and graph convolutional network for predicting breast cancer drug response [0.03%]
集成自编码器和图卷积网络以预测乳腺癌药物反应
V Abinas,U Abhinav,E M Haneem et al.
V Abinas et al.
Background and objectives: Breast cancer is the most prevalent type of cancer among women. The effectiveness of anticancer pharmacological therapy may get adversely affected by tumor heterogeneity that includes genetic and transcriptomic fe...
Construction of transcript regulation mechanism prediction models based on binding motif environment of transcription factor AoXlnR in Aspergillus oryzae [0.03%]
基于黑曲霉转录因子AoXlnR结合基序环境的转录调控机制预测模型构建
Hiroya Oka,Takaaki Kojima,Ryuji Kato et al.
Hiroya Oka et al.
DNA-binding transcription factors (TFs) play a central role in transcriptional regulation mechanisms, mainly through their specific binding to target sites on the genome and regulation of the expression of downstream genes. Therefore, a com...