CD20 xCD3 bispecific antibodies for large B cell lymphoma: latest updates from 2024 ASH annual meeting [0.03%]
2024年ASH年会关于CD20×CD3双特异性抗体治疗大B细胞淋巴瘤的最新进展
V Tomarchio,L Rigacci,O Annibali
V Tomarchio
Bispecific antibodies (BsAbs) represent an innovative class of off-the-shelf T-cell redirecting agents and are considered among the most promising immunotherapeutic strategies for the treatment of lymphoma. Notably, anti-CD20 × CD3 BsAbs h...
KRAS mutation detection by liquid biopsy for pancreatic ductal adenocarcinoma [0.03%]
胰腺导管腺癌患者采用液态活检技术检测KRAS突变
Mahmoud Yousef,Abdelrahman Yousef,Mark W Hurd et al.
Mahmoud Yousef et al.
The clinical utility of liquid biopsy (LB) for pancreatic ductal adenocarcinoma (PDAC) remain understudied. Our single-institution cohort of 311 PDAC patients with non-tumor tissues informed LB found 81.2% positivity (N = 186) in metastatic...
Nanomaterials-driven in situ vaccination: a novel frontier in tumor immunotherapy [0.03%]
基于纳米材料的原位疫苗接种疗法：肿瘤免疫治疗的新前沿
Naimeng Liu,Xiangyu Wang,Zhongzhao Wang et al.
Naimeng Liu et al.
In situ vaccination (ISV) has emerged as a promising strategy in cancer immunotherapy, offering a targeted approach that uses the tumor microenvironment (TME) to stimulate an immune response directly at the tumor site. This method minimizes...
Replicon RNA vaccines: design, delivery, and immunogenicity in infectious diseases and cancer [0.03%]
复制型RNA疫苗：设计、递送及在传染病和癌症中的免疫原性
Lirui Tang,Haiying Que,Yuquan Wei et al.
Lirui Tang et al.
Replicon RNA (RepRNA) represents a cutting-edge technology in the field of vaccinology, fundamentally transforming vaccine design and development. This innovative approach facilitates the induction of robust immune responses against a range...
The current landscape of gastric cancer and gastroesophageal junction cancer diagnosis and treatment in China: a comprehensive nationwide cohort analysis [0.03%]
中国胃癌和食管胃交界处癌症诊断和治疗的现状：全面的全国队列分析
Yang Chen,Keren Jia,Yi Xie et al.
Yang Chen et al.
Background: Gastric cancer is the fifth most common cancer globally and is associated with significant morbidity and mortality. Despite its alarming prevalence, limited comparative evidence exists on its treatment efficac...
The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior [0.03%]
R-RAS2 GTPase在三阴性乳腺癌细胞代谢和转移行为中的信号转导中心作用
Claudia Cifuentes,Lydia Horndler,Pilar Grosso et al.
Claudia Cifuentes et al.
Background: Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies. Thi...
The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications [0.03%]
cGAS-STING通路在癌症免疫中的作用：机制、挑战和治疗意义
Mengzhou Shen,Xianjie Jiang,Qiu Peng et al.
Mengzhou Shen et al.
Innate immunity represents the body's first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established functio...
Non-canonical small noncoding RNAs in the plasma extracellular vesicles as novel biomarkers in gastric cancer [0.03%]
胃癌患者血浆外泌体中的非经典微小非编码RNA作为新的生物标志物
Ping Yang,Zhibo Li,Xi Chen et al.
Ping Yang et al.
Identifying robust diagnostic biomarkers for gastric cancer (GC) remains a significant challenge. Emerging studies highlight extracellular vesicle (EV)-derived RNAs in cancer biology, but the diagnostic potential of circulating EV-derived s...
C3G promotes bone marrow adipocyte expansion and hematopoietic regeneration after myeloablation by enhancing megakaryocyte niche function [0.03%]
C3G通过增强巨核细胞龛的功能促进骨髓脂肪细胞的增生及造血功能的重建
Óscar Herranz,Pablo Berrocal,Carmen Sicilia-Navarro et al.
Óscar Herranz et al.
C3G, a Rap1 GEF, promotes megakaryopoiesis and platelet function. Using transgenic and knock-out mouse models targeting C3G in megakaryocytes, we investigated whether C3G also affects the niche function of megakaryocytes during bone marrow ...
Xiaoqian Zhai,Zhengkun Zhang,Yuxin Chen et al.
Xiaoqian Zhai et al.
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation and high metastatic potential. It is characterized by universal inactivation of and RB1, overexpression of the MYC family and dysregulation of mu...