Recent advances in S-palmitoylation and its emerging roles in human diseases [0.03%]
S-棕榈酰化研究的最新进展及其在人类疾病中的新作用
Juanjuan Shang,Mei Ding,Xiangxiang Zhou
Juanjuan Shang
S-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions. Through S-palmitoylation, proteins can be targeted to specif...
Ning Jiang,Zhaoyi Yang,Huilei Miao et al.
Ning Jiang et al.
While chimeric antigen receptor (CAR) T cell therapy is highly effective for hematological malignancies, its widespread use is limited by complex, patient-specific manufacturing. Universal CAR-T (UCAR-T) cells, derived from allogeneic donor...
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges [0.03%]
免疫衰老与癌症：分子特征、肿瘤微环境重塑及年龄特异性免疫治疗挑战
Qianwen Liu,Jingfeng Li,Xiuqiao Sun et al.
Qianwen Liu et al.
Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by fostering a tumor-promoting microenvironment and impairing immune surveillance. This review delineates eleven mo...
Clinical applications of circulating tumor cells in metastasis and therapy [0.03%]
循环肿瘤细胞在转移和治疗中的临床应用
Chuan Yang,Can Liu,Chenglai Xia et al.
Chuan Yang et al.
Circulating tumor cells (CTCs), which serve as an early indicator of tumors in peripheral blood, are closely associated with unfavorable prognoses in individuals with cancer. Gaining a thorough understanding of the heterogeneity and specifi...
Ye Feng,Guang Liu,Haiqing Li et al.
Ye Feng et al.
Neutrophils have long been regarded as cells of a limited lifespan, known to produce pro-inflammatory molecules, and primarily engaged in combating infections. However, recent advancements in single-cell analysis and molecular biology have ...
Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies [0.03%]
线粒体自噬对癌症和神经退行性疾病的影响及其未来治疗意义
Jason Huang,Vincent Truong Pham,Shaozi Fu et al.
Jason Huang et al.
Substantial evidence supports an inverse relationship between cancer and neurodegenerative diseases (NDDs), but few studies investigate the biological mechanisms underlying this phenomenon. While previous explanations-such as inflammation, ...
Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications [0.03%]
表观遗传、转录后和翻译后修饰介导的坏死性凋亡在肿瘤中的作用及机制探究
Jinxin Tang,Yan Zhuang,Yibo Zhang et al.
Jinxin Tang et al.
Necroptosis represents a distinct form of programmed cell death that exhibits characteristics of both necrosis and apoptosis. Due to its potential to activate anti-cancer immune responses, utilizing necroptosis to enhance immune activity wi...
Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide [0.03%]
针对小细胞肺癌的CD276构建adapter-CART细胞提供了一种新的治疗策略并预防CD276依赖性同族杀伤作用
Beate Kristmann,Niels Werchau,Lakshmi Suresh et al.
Beate Kristmann et al.
Background: Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activ...
Iparomlimab and tuvonralimab (QL1706) plus chemotherapy and bevacizumab for EGFR-mutant patients with advanced non-small cell lung cancer after failure of EGFR-tyrosine kinase inhibitors: updated results from cohort 5 in the DUBHE-L-201 study [0.03%]
伊帕伐单抗和图卡伐单抗（QL1706）联合化疗及贝伐珠单抗治疗EGFR突变型晚期非小细胞肺癌患者厄洛替尼/吉非替尼耐药后患者的Ⅱ期临床研究队列5结果更新
Yaxiong Zhang,Yan Huang,Yunpeng Yang et al.
Yaxiong Zhang et al.
Iparomlimab and tuvonralimab (QL1706), a bifunctional anti-programmed death-1/cytotoxic T-lymphocyte antigen-4 antibody, in combination with bevacizumab and doublet chemotherapy was tolerable and showed preliminary antitumor activity in adv...
Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study [0.03%]
套细胞淋巴瘤伴t(14;19)(q32;q13)的侵袭性CLL的环状RNA特征（ERIC研究）
Eleonora Roncaglia,Enrico Gaffo,Giulia Calabretto et al.
Eleonora Roncaglia et al.
In Chronic Lymphocytic Leukemia (CLL), t(14;19)(q32;q13), leading to the overexpression of BCL3, is found in ∼1% of cases and is associated with an aggressive disease. In this study, leveraging a large CLL patient cohort collected thanks t...