Therapeutic landscape of primary refractory and relapsed diffuse large B-cell lymphoma: Recent advances and emerging therapies [0.03%]
初治难治及复发弥漫性大B细胞淋巴瘤的治疗现状、 recent advances and emerging therapies
Allison M Bock,Narendranath Epperla
Allison M Bock
Diffuse large B-cell lymphoma (DLBCL) is an aggressive, yet curable malignancy, that has had practice changing treatment approvals in both the frontline and relapsed setting in the last 5 years. Advent of novel therapeutic options in the re...
Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution [0.03%]
单细胞分辨率解析胆管癌异质性和额外肝胆管癌祖细胞生态位
Chunliang Liu,Xiang Wang,Erdong Liu et al.
Chunliang Liu et al.
Background: Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy, primarily comprising intrahepatic (iCCA) and extrahepatic (eCCA) subtypes. Reconciling the variability between iCCAs and eCCAs in clinical trials ...
Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy [0.03%]
肿瘤免疫调节的细胞外基质动力学：从肿瘤微环境到免疫治疗
Qin Hu,Yifei Zhu,Jie Mei et al.
Qin Hu et al.
The extracellular matrix (ECM), closely linked to the dynamic changes in the tumor microenvironment (TME), plays a critical role in modulating tumor immunity. The dual role of the ECM in tumor progression, encompassing both promotion and in...
Correction: Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy [0.03%]
订正：Ube2v1介导的Sirt1泛素化降解通过表观遗传抑制自噬促进结直肠癌转移
Tong Shen,Ling-Dong Cai,Yu-Hong Liu et al.
Tong Shen et al.
Published Erratum
Journal of hematology & oncology. 2025 Jun 17;18(1):64. DOI:10.1186/s13045-025-01719-w 2025
Menin inhibitors from monotherapies to combination therapies: clinical trial updates from 2024 ASH annual meeting [0.03%]
ARNI从单药治疗到联合治疗的临床试验进展——2024年ASH年会更新
Gejia Cao,Haixiao Zhang,Shu Sun et al.
Gejia Cao et al.
Menin inhibitors, which target the KMT2A-menin protein-protein interaction to inhibit blasts proliferation and induce differentiation, have demonstrated potential effects on acute leukemia subtypes characterized by overexpression of HOXA ge...
Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic prospects [0.03%]
下一代免疫治疗设计与工具的研究进展：分子机制和转化前景
Hongzhuo Qin,Zhaokai Zhou,Run Shi et al.
Hongzhuo Qin et al.
Immunotherapy has revolutionized the oncology treatment paradigm, and CAR-T cell therapy in particular represents a significant milestone in treating hematological malignancies. Nevertheless, tumor resistance due to target heterogeneity or ...
Results of a phase 1/2 study of sacituzumab tirumotecan in patients with unresectable locally advanced or metastatic solid tumors refractory to standard therapies [0.03%]
司妥昔单抗-替莫卢单药治疗标准疗法耐药的不可切除局部晚期或转移性实体瘤患者的Ib/II期研究结果
Quchang Ouyang,Jordi Rodon,Yan Liang et al.
Quchang Ouyang et al.
Background: Sacituzumab tirumotecan (sac-TMT) is an antibody-drug conjugate composed of an anti-TROP2 monoclonal antibody coupled to a cytotoxic belotecan-derived topoisomerase I inhibitor (KL610023) via a novel linker. W...
Correction: BCMA/GPRC5D bispecific CAR T-cell therapy for relapsed/refractory multiple myeloma with extramedullary disease: a single-center, single-arm, phase 1 trial [0.03%]
纠正：BCMA/GPRC5D 双特异性CAR-T细胞治疗难治性和复发性多发性骨髓瘤伴髓外病变：一项单中心、单组、I期试验
Hao Yao,Shi-Hui Ren,Lin-Hui Wang et al.
Hao Yao et al.
Published Erratum
Journal of hematology & oncology. 2025 Jun 3;18(1):60. DOI:10.1186/s13045-025-01714-1 2025
Integrated clinical and proteomic-based model for diagnostic and prognostic prediction in pRCC [0.03%]
基于临床和蛋白质组的I型透明细胞肾癌诊断和预测模型
Zeya Xu,Linhui Zhang,Jiacheng Lyu et al.
Zeya Xu et al.
Papillary renal cell carcinoma (pRCC), a main pathological subtype of non-clear cell RCC (nccRCC), has strong heterogeneity. Comparing to other nccRCC subtypes, advanced pRCC has the poorest prognosis. Due to its lower incidence compared to...
Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas [0.03%]
全景空间增强分辨率蛋白质组学（PSERP）揭示了胶质瘤的肿瘤结构和异质性
Ziyan Xu,Yunzhi Wang,Tao Xie et al.
Ziyan Xu et al.
The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. However, the imbalance among resolution, protein coverage, and expense precludes their systematic ...