HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors [0.03%]
HCB101：一种针对CD47-SIRPα通路的新型强效配体陷捕型融合蛋白，具有高度安全性和临床前抗血液系统和实体肿瘤活性
Jiin-Tarng Wang,Chi-Ling Tseng,Han-Fang Teng et al.
Jiin-Tarng Wang et al.
Cluster of differentiation 47 (CD47) delivers an inhibitory signal that suppresses phagocytosis and prevents immune clearance of tumor cells by interacting with signal regulatory protein alpha (SIRPα) on myeloid cells. Although blockade of...
Targeting triple-negative breast cancer using cord-blood CD34⁺ HSPC-derived mesothelin-specific CAR-NKT cells with potent antitumor activity [0.03%]
靶向三阴性乳腺癌的胎盘血CD34⁺多能造血干细胞来源的以mesothelin为靶点、具有强抗肿瘤活性的CAR-NKT细胞疗法
Yan-Ruide Li,Xinyuan Shen,Yichen Zhu et al.
Yan-Ruide Li et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of ER, PR, and HER2 expression. Its aggressive behavior, high degree of tumor heterogeneity, and immunos...
Combination immunotherapy in hepatocellular carcinoma: synergies among immune checkpoints, TKIs, and chemotherapy [0.03%]
肝细胞癌的免疫联合疗法：免疫检查点、TKI和化疗之间的协同作用
Suoyi Dai,Yuhang Chen,Wenxun Cai et al.
Suoyi Dai et al.
Combination therapy is rapidly becoming the cornerstone of hepatocellular carcinoma (HCC) treatment. Immune checkpoint inhibitors (ICIs) have emerged as a central strategy in systemic therapy, yet their efficacy as monotherapies remains lim...
The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives [0.03%]
肿瘤新抗原和突变负荷在癌症免疫治疗中的作用：进展、机制与展望
Shengbo Sun,Lanchun Liu,Jingkang Zhang et al.
Shengbo Sun et al.
Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors. Among various biomarkers, neoantigens and tumor mutational burden (TMB) have emerged as critical factors in tailoring personalized treatments...
Recent advances in S-palmitoylation and its emerging roles in human diseases [0.03%]
S-棕榈酰化研究的最新进展及其在人类疾病中的新作用
Juanjuan Shang,Mei Ding,Xiangxiang Zhou
Juanjuan Shang
S-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions. Through S-palmitoylation, proteins can be targeted to specif...
Ning Jiang,Zhaoyi Yang,Huilei Miao et al.
Ning Jiang et al.
While chimeric antigen receptor (CAR) T cell therapy is highly effective for hematological malignancies, its widespread use is limited by complex, patient-specific manufacturing. Universal CAR-T (UCAR-T) cells, derived from allogeneic donor...
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges [0.03%]
免疫衰老与癌症：分子特征、肿瘤微环境重塑及年龄特异性免疫治疗挑战
Qianwen Liu,Jingfeng Li,Xiuqiao Sun et al.
Qianwen Liu et al.
Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by fostering a tumor-promoting microenvironment and impairing immune surveillance. This review delineates eleven mo...
Clinical applications of circulating tumor cells in metastasis and therapy [0.03%]
循环肿瘤细胞在转移和治疗中的临床应用
Chuan Yang,Can Liu,Chenglai Xia et al.
Chuan Yang et al.
Circulating tumor cells (CTCs), which serve as an early indicator of tumors in peripheral blood, are closely associated with unfavorable prognoses in individuals with cancer. Gaining a thorough understanding of the heterogeneity and specifi...
Ye Feng,Guang Liu,Haiqing Li et al.
Ye Feng et al.
Neutrophils have long been regarded as cells of a limited lifespan, known to produce pro-inflammatory molecules, and primarily engaged in combating infections. However, recent advancements in single-cell analysis and molecular biology have ...
Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies [0.03%]
线粒体自噬对癌症和神经退行性疾病的影响及其未来治疗意义
Jason Huang,Vincent Truong Pham,Shaozi Fu et al.
Jason Huang et al.
Substantial evidence supports an inverse relationship between cancer and neurodegenerative diseases (NDDs), but few studies investigate the biological mechanisms underlying this phenomenon. While previous explanations-such as inflammation, ...