Qinghua He,Zhaoyu Liu,Zhihua Liu et al.
Qinghua He et al.
Cancer immunotherapy has been regarded as the most significant scientific breakthrough of 2013, and antibody therapy is at the core of this breakthrough. Despite significant success achieved in recent years, it is still difficult to target ...
Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer [0.03%]
长非编码RNA GSTM3TV2通过竞争性结合let-7上调LAT2和OLR1促进胰腺癌耐吉西他滨化疗
Guangbing Xiong,Chang Liu,Gang Yang et al.
Guangbing Xiong et al.
Background: Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outco...
Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study [0.03%]
全球疾病负担研究中的癌症疾病负担及1990年至2017年间的趋势（基于2017年的数据）
Longfei Lin,Lei Yan,Yuling Liu et al.
Longfei Lin et al.
Background and aims: Cancer has become the second most serious disease threatening human health, followed by cardiovascular diseases. This study aimed to quantitatively estimate the mortality, morbidity, and analyze the t...
Qi Wu,Bei Li,Zhiyu Li et al.
Qi Wu et al.
Adipocytes are one of the primary stromal cells in many tissues, and they are considered to play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) are not only found adjacent to cancer cells, but also communi...
Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma [0.03%]
治疗淋巴系统恶性肿瘤和多发性骨髓瘤的药物抗体连接物临床试验
Bo Yu,Delong Liu
Bo Yu
Antibody-drug conjugates (ADC) represent a distinct family of chemoimmunotherapy agents. ADCs are composed of monoclonal antibodies conjugated to cytotoxic payloads via specialized chemical linkers. ADCs therefore combine the immune therapy...
Tao Jiang,Tao Shi,Henghui Zhang et al.
Tao Jiang et al.
Tumor neoantigen is the truly foreign protein and entirely absent from normal human organs/tissues. It could be specifically recognized by neoantigen-specific T cell receptors (TCRs) in the context of major histocompatibility complexes (MHC...
LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis [0.03%]
长链非编码RNA LINC01123通过miR-199a-5p/c-Myc轴促进非小细胞肺癌的增殖和糖酵解
Qian Hua,Mingming Jin,Baoming Mi et al.
Qian Hua et al.
Background: Long non-coding RNAs (lncRNAs) have been associated with non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific roles in mediating aerobic glycolysis have been poorly exp...
Akintunde Akinleye,Zoaib Rasool
Akintunde Akinleye
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-L1) for a subset of cancer pati...
Tao Yu,Yanfen Wang,Yu Fan et al.
Tao Yu et al.
Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid and amino acid are orchestrated not only by...
Kevin Zarrabi,Azzam Paroya,Shenhong Wu
Kevin Zarrabi
The treatment of genitourinary malignancies has dramatically evolved over recent years. Renal cell carcinoma, urothelial carcinoma of the bladder, and prostate adenocarcinoma are the most commonly encountered genitourinary malignancies and ...