The current landscape of gastric cancer and gastroesophageal junction cancer diagnosis and treatment in China: a comprehensive nationwide cohort analysis [0.03%]
中国胃癌和食管胃交界处癌症诊断和治疗的现状：全面的全国队列分析
Yang Chen,Keren Jia,Yi Xie et al.
Yang Chen et al.
Background: Gastric cancer is the fifth most common cancer globally and is associated with significant morbidity and mortality. Despite its alarming prevalence, limited comparative evidence exists on its treatment efficac...
The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior [0.03%]
R-RAS2 GTPase在三阴性乳腺癌细胞代谢和转移行为中的信号转导中心作用
Claudia Cifuentes,Lydia Horndler,Pilar Grosso et al.
Claudia Cifuentes et al.
Background: Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies. Thi...
The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications [0.03%]
cGAS-STING通路在癌症免疫中的作用：机制、挑战和治疗意义
Mengzhou Shen,Xianjie Jiang,Qiu Peng et al.
Mengzhou Shen et al.
Innate immunity represents the body's first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established functio...
Non-canonical small noncoding RNAs in the plasma extracellular vesicles as novel biomarkers in gastric cancer [0.03%]
胃癌患者血浆外泌体中的非经典微小非编码RNA作为新的生物标志物
Ping Yang,Zhibo Li,Xi Chen et al.
Ping Yang et al.
Identifying robust diagnostic biomarkers for gastric cancer (GC) remains a significant challenge. Emerging studies highlight extracellular vesicle (EV)-derived RNAs in cancer biology, but the diagnostic potential of circulating EV-derived s...
C3G promotes bone marrow adipocyte expansion and hematopoietic regeneration after myeloablation by enhancing megakaryocyte niche function [0.03%]
C3G通过增强巨核细胞龛的功能促进骨髓脂肪细胞的增生及造血功能的重建
Óscar Herranz,Pablo Berrocal,Carmen Sicilia-Navarro et al.
Óscar Herranz et al.
C3G, a Rap1 GEF, promotes megakaryopoiesis and platelet function. Using transgenic and knock-out mouse models targeting C3G in megakaryocytes, we investigated whether C3G also affects the niche function of megakaryocytes during bone marrow ...
Xiaoqian Zhai,Zhengkun Zhang,Yuxin Chen et al.
Xiaoqian Zhai et al.
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation and high metastatic potential. It is characterized by universal inactivation of and RB1, overexpression of the MYC family and dysregulation of mu...
Hongyuan Jia,Xingmin Chen,Linling Zhang et al.
Hongyuan Jia et al.
Cancer-associated fibroblasts (CAFs) are key players in cancer development and therapy, and they exhibit multifaceted roles in the tumor microenvironment (TME). From their diverse cellular origins, CAFs undergo phenotypic and functional tra...
Po-Lan Su,Naoki Furuya,Alahmadi Asrar et al.
Po-Lan Su et al.
The development of targeted therapy with small-molecule tyrosine kinase inhibitors and immunotherapy with immune checkpoints inhibitors has ushered in the era of precision medicine in treating lung cancer, which remains the leading cause of...
Correction: WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome [0.03%]
修正：WT1-mRNA树突状细胞疫苗治疗多形性胶质母细胞瘤，恶性胸膜间皮瘤，转移性乳腺癌和其它实体肿瘤患者：类型1T淋巴细胞反应与临床结果相关
Zwi N Berneman,Maxime De Laere,Paul Germonpré et al.
Zwi N Berneman et al.
Published Erratum
Journal of hematology & oncology. 2025 Mar 19;18(1):34. DOI:10.1186/s13045-025-01683-5 2025
Correction: myCAF-derived Exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment [0.03%]
修正：来自myCAF的胞外囊泡PWAR6通过改变肿瘤微环境中的谷氨酰胺可用性和NK细胞功能来加速结直肠癌肝转移
Hongsheng Fang,Weixing Dai,Ruiqi Gu et al.
Hongsheng Fang et al.
Published Erratum
Journal of hematology & oncology. 2025 Mar 18;18(1):31. DOI:10.1186/s13045-025-01685-3 2025