M Angeles Montero-Fernandez,Ricardo Pardo-Garcia
M Angeles Montero-Fernandez
COVID-19 is the infectious disease caused by the recently discovered coronavirus, SARS-CoV-2, unknown before the outbreak in Wuhan, China, in December 2019. COVID-19 is a pandemic, infectious disease that has simultaneously affected many co...
The practice of cytopathology during the era of COVID-19: challenges and changes [0.03%]
COVID-19时代的细胞病理学实践：挑战和改变
Swikrity Upadhyay Baskota,Ashish Chandra,Paul Cross
Swikrity Upadhyay Baskota
This paper reviews the challenges faced by cytology laboratories during the COVID-19 pandemic. Various safety guidelines regarding collection, handling, transport and sampling in cytology laboratory are presented. A brief literature overvie...
Tim Helliwell
Tim Helliwell
Inflammatory diseases of the nose and paranasal sinus are commonly encountered in diagnostic histopathology. This review describes the possible manifestations of the common diseases as well as highlighting some of the uncommon causes of sin...
Mark F Evans
Mark F Evans
Pathology practice is increasingly augmented with molecular tests for improved diagnostics and patient management. The polymerase chain reaction (PCR) is foremost amongst these techniques. This review explains the principles of PCR and the ...
Pooja Virmani,Patricia L Myskowski,Melissa Pulitzer
Pooja Virmani
Conventional presentations of mycosis fungoides may be diagnostically challenging, particularly in light of the controversial boundaries defining the disease. Variant presentations of this cutaneous T-cell lymphoma add a further layer of co...
Study design [0.03%]
研究设计
Vernon T Farewell,Daniel M Farewell
Vernon T Farewell
A brief survey is provided of common designs for medical studies and important issues in their implementation. The designs discussed include those for laboratory studies, clinical trials, cohort studies, case-control and related studies, an...
Use of human specimens in research: the evolving United States regulatory, policy, and scientific landscape [0.03%]
人体样本在研究中的应用：美国监管、政策和科学领域的变迁格局
Marianna J Bledsoe,William E Grizzle
Marianna J Bledsoe
The use of human specimens in research has contributed to significant scientific and medical advancements. However, the development of sophisticated whole genome and informatics technologies and the increase in specimen and data sharing hav...
Alvaro P Pinto,Christopher P Crum,Michelle S Hirsch
Alvaro P Pinto
Pure morphological distinction of high-grade squamous intraepithelial lesions (HSILs) from their mimics can be challenging. Diagnosis can be difficult with nonconventional HSILs associated with a metaplastic phenotype, squamous intraepithel...
Cystic lesions of the pancreas [0.03%]
胰腺囊性病变
Ralph H Hruban,Noriyoshi Fukushima
Ralph H Hruban
In contrast to the relatively uniform pathology and the unyielding dismal outcome associated with infiltrating ductal adenocarcinoma of the pancreas, cystic lesions have a broad spectrum of gross and microscopic pathologies, and a range of ...
The pathogenesis of prostate cancer: from molecular to metabolic alterations [0.03%]
前列腺癌的发病机制：从分子到代谢改变
Elisa Benedettini,Paul Nguyen,Massimo Loda
Elisa Benedettini
Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiolog...