Statistical quality assessment and outlier detection for liquid chromatography-mass spectrometry experiments [0.03%]
液相色谱-质谱实验的质量评估与异常值检测的统计方法
Ole Schulz-Trieglaff,Egidijus Machtejevas,Knut Reinert et al.
Ole Schulz-Trieglaff et al.
Background: Quality assessment methods, that are common place in engineering and industrial production, are not widely spread in large-scale proteomics experiments. But modern technologies such as Multi-Dimensional Liquid...
Sondes Fayech,Nadia Essoussi,Mohamed Limam
Sondes Fayech
Background: Genome-sequencing projects are currently producing an enormous amount of new sequences and cause the rapid increasing of protein sequence databases. The unsupervised classification of these data into functiona...
Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms [0.03%]
多重维度减少分析确定了促进基因多态性的特定核苷酸模式
Eric Arehart,Scott Gleim,Bill White et al.
Eric Arehart et al.
Background: The fidelity of DNA replication serves as the nidus for both genetic evolution and genomic instability fostering disease. Single nucleotide polymorphisms (SNPs) constitute greater than 80% of the genetic varia...
Database mining for selection of SNP markers useful in admixture mapping [0.03%]
从数据库中挖掘可用于族群杂交系谱分析的SNP标记
Tesfaye M Baye,Hemant K Tiwari,David B Allison et al.
Tesfaye M Baye et al.
Background: New technologies make it possible for the first time to genotype hundreds of thousands of SNPs simultaneously. A wealth of genomic information in the form of publicly available databases is underutilized as a ...
Georgios A Pavlopoulos,Anna-Lynn Wegener,Reinhard Schneider
Georgios A Pavlopoulos
The analysis and interpretation of relationships between biological molecules, networks and concepts is becoming a major bottleneck in systems biology. Very often the pure amount of data and their heterogeneity provides a challenge for the ...
Kristian Ovaska,Marko Laakso,Sampsa Hautaniemi
Kristian Ovaska
Background: Analysis of a microarray experiment often results in a list of hundreds of disease-associated genes. In order to suggest common biological processes and functions for these genes, Gene Ontology annotations wit...
Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processing [0.03%]
基于图像处理的神经元亚细胞器在神经退行性疾病相关变化中的多变量分析方法探究
Saravana K Kumarasamy,Yunshi Wang,Vignesh Viswanathan et al.
Saravana K Kumarasamy et al.
Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in particular Alzheimer's disease. However, the su...
Haiying Wang,Huiru Zheng,Francisco Azuaje
Haiying Wang
Serial analysis of gene expression (SAGE) is one of the most powerful tools for global gene expression profiling. It has led to several biological discoveries and biomedical applications, such as the prediction of new gene functions and the...
Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles [0.03%]
利用基因表达谱系统挖掘顺式调控元件从而揭示转录调控机制
Qicheng Ma,Gung-Wei Chirn,Joseph D Szustakowski et al.
Qicheng Ma et al.
Background: Contrary to the traditional biology approach, where the expression patterns of a handful of genes are studied at a time, microarray experiments enable biologists to study the expression patterns of many genes ...
Jesús S Aguilar-Ruiz,Jason H Moore,Marylyn D Ritchie
Jesús S Aguilar-Ruiz
This editorial introduces BioData Mining, a new journal which publishes research articles related to advances in computational methods and techniques for the extraction of useful knowledge from heterogeneous biological data. We outline the ...