Mining beyond the exome [0.03%]
全外显子组以外的挖掘分析
Davnah Urbach,Jason H Moore
Davnah Urbach
Shuying Sun,Yi-Wen Huang,Pearlly S Yan et al.
Shuying Sun et al.
Background: DNA methylation plays a very important role in the silencing of tumor suppressor genes in various tumor types. In order to gain a genome-wide understanding of how changes in methylation affect tumor growth, th...
A comparison of machine learning techniques for survival prediction in breast cancer [0.03%]
用于乳腺癌生存预测的机器学习技术比较
Leonardo Vanneschi,Antonella Farinaccio,Giancarlo Mauri et al.
Leonardo Vanneschi et al.
Background: The ability to accurately classify cancer patients into risk classes, i.e. to predict the outcome of the pathology on an individual basis, is a key ingredient in making therapeutic decisions. In recent years g...
The effects of linkage disequilibrium in large scale SNP datasets for MDR [0.03%]
基于MDR的大型SNP数据集的连锁不平衡效应分析
Benjamin J Grady,Eric S Torstenson,Marylyn D Ritchie
Benjamin J Grady
Background: In the analysis of large-scale genomic datasets, an important consideration is the power of analytical methods to identify accurate predictive models of disease. When trying to assess sensitivity from such ana...
Georgios A Pavlopoulos,Maria Secrier,Charalampos N Moschopoulos et al.
Georgios A Pavlopoulos et al.
Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be done by examining the elementary ...
pGQL: A probabilistic graphical query language for gene expression time courses [0.03%]
pGQL：一种基因表达时间过程的概率图查询语言
Ruben Schilling,Ivan G Costa,Alexander Schliep
Ruben Schilling
Background: Timeboxes are graphical user interface widgets that were proposed to specify queries on time course data. As queries can be very easily defined, an exploratory analysis of time course data is greatly facilitat...
A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR [0.03%]
Partek Genomic Solutions、基因分型控制台和Birdsuite算法与定量PCR比较基因组拷贝数呼叫
Britney L Grayson,Thomas M Aune
Britney L Grayson
Background: Copy number variants are >1 kb genomic amplifications or deletions that can be identified using array platforms. However, arrays produce substantial background noise that contributes to high false discovery ra...
Davnah Urbach,Jason H Moore
Davnah Urbach
Davnah Urbach,Jason H Moore
Davnah Urbach
Alignment of gene expression profiles from test samples against a reference database: New method for context-specific interpretation of microarray data [0.03%]
测试样本基因表达谱与参考数据库的匹配：微阵列数据的上下文特异性解释的新方法
Sami K Kilpinen,Kalle A Ojala,Olli P Kallioniemi
Sami K Kilpinen
Background: Gene expression microarray data have been organized and made available as public databases, but the utilization of such highly heterogeneous reference datasets in the interpretation of data from individual tes...