Stacey J Winham,Alison A Motsinger-Reif
Stacey J Winham
Background: A breadth of high-dimensional data is now available with unprecedented numbers of genetic markers and data-mining approaches to variable selection are increasingly being utilized to uncover associations, inclu...
Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction [0.03%]
基于蛋白质结构预测的进化方法及其爬山搜索和多样性研究
Camelia Chira,Dragos Horvath,D Dumitrescu
Camelia Chira
Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process. However, the general principles that govern t...
Detection of putative new mutacins by bioinformatic analysis using available web tools [0.03%]
利用网上工具进行生物信息学分析鉴定潜在的新突变蛋白质
Guillaume G Nicolas
Guillaume G Nicolas
In order to characterise new bacteriocins produced by Streptococcus mutans we perform a complete bioinformatic analyses by scanning the genome sequence of strains UA159 and NN2025. By searching in the adjacent genomic context of the two-com...
Evolving hard problems: Generating human genetics datasets with a complex etiology [0.03%]
复杂遗传基因数据集的生成研究
Daniel S Himmelstein,Casey S Greene,Jason H Moore
Daniel S Himmelstein
Background: A goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the joint failure of two or more interacti...
Taxon ordering in phylogenetic trees by means of evolutionary algorithms [0.03%]
利用遗传算法对系统发育树中的分类次序排序的方法研究
Francesco Cerutti,Luigi Bertolotti,Tony L Goldberg et al.
Francesco Cerutti et al.
Background: In in a typical "left-to-right" phylogenetic tree, the vertical order of taxa is meaningless, as only the branch path between them reflects their degree of similarity. To make unresolved trees more informative...
DADA: Degree-Aware Algorithms for Network-Based Disease Gene Prioritization [0.03%]
基于网络的度感知算法用于疾病基因优先级划分
Sinan Erten,Gurkan Bebek,Rob M Ewing et al.
Sinan Erten et al.
Background: High-throughput molecular interaction data have been used effectively to prioritize candidate genes that are linked to a disease, based on the observation that the products of genes associated with similar dis...
Discrete derivative: a data slicing algorithm for exploration of sharing biological networks between rheumatoid arthritis and coronary heart disease [0.03%]
离散导数：用于探究类风湿性关节炎和冠心病之间共享生物网络的探索的数据切片算法
Guang Zheng,Miao Jiang,Xiaojuan He et al.
Guang Zheng et al.
Background: One important concept in traditional Chinese medicine (TCM) is "treating different diseases with the same therapy". In TCM practice, some patients with Rheumatoid Arthritis (RA) and some other patients with Co...
Jun-Ichi Satoh,Hiroko Tabunoki
Jun-Ichi Satoh
Background: MicroRNAs (miRNAs) mediate posttranscriptional regulation of protein-coding genes by binding to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradat...
Dominik Heider,Daniel Hoffmann
Dominik Heider
Background: Most machine learning techniques currently applied in the literature need a fixed dimensionality of input data. However, this requirement is frequently violated by real input data, such as DNA and protein sequ...
Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation [0.03%]
通过动画可视化多个实验检测由Hsp90分子伴侣复合物扰动引起的基因调控模式的变化
Pablo C Echeverría,Fedor Forafonov,Deo P Pandey et al.
Pablo C Echeverría et al.
Background: To make sense out of gene expression profiles, such analyses must be pushed beyond the mere listing of affected genes. For example, if a group of genes persistently display similar changes in expression levels...