A comparison and evaluation of five biclustering algorithms by quantifying goodness of biclusters for gene expression data [0.03%]
通过量化基因表达数据双矩阵块质量比较和评估五种双矩阵模块算法
Li Li,Yang Guo,Wenwu Wu et al.
Li Li et al.
Background: Several biclustering algorithms have been proposed to identify biclusters, in which genes share similar expression patterns across a number of conditions. However, different algorithms would yield different bi...
'MicroRNA Targets', a new AthaMap web-tool for genome-wide identification of miRNA targets in Arabidopsis thaliana [0.03%]
'AthaMap新的“微rna靶点”网络工具可对阿拉伯芥中的miRNA靶点进行全基因组鉴定'
Lorenz Bülow,Julio C Bolívar,Jonas Ruhe et al.
Lorenz Bülow et al.
Background: The AthaMap database generates a genome-wide map for putative transcription factor binding sites for A. thaliana. When analyzing transcriptional regulation using AthaMap it may be important to learn which gene...
How do alignment programs perform on sequencing data with varying qualities and from repetitive regions? [0.03%]
不同测序质量和重复区域的序列数据如何影响比对效果？
Xiaoqing Yu,Kishore Guda,Joseph Willis et al.
Xiaoqing Yu et al.
Background: Next-generation sequencing technologies generate a significant number of short reads that are utilized to address a variety of biological questions. However, quite often, sequencing reads tend to have low qual...
Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View [0.03%]
基于PheWAS-View的高通量表型关联分析(PheWAS)结果可视化集成与探索
Sarah A Pendergrass,Scott M Dudek,Dana C Crawford et al.
Sarah A Pendergrass et al.
Background: Phenome-Wide Association Studies (PheWAS) can be used to investigate the association between single nucleotide polymorphisms (SNPs) and a wide spectrum of phenotypes. This is a complementary approach to Genome...
Jiang Gui,Tor D Tosteson,Mark Borsuk
Jiang Gui
With the rapid development of biological technology, measurement of thousands of genes or SNPs can be carried out simultaneously. Improved procedures for multiple hypothesis testing when the number of tests is very large are critical for in...
Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes [0.03%]
用于选择目标基因最优数量的多重维度减少模型的全局P值检验方法研究
Hongying Dai,Madhusudan Bhandary,Mara Becker et al.
Hongying Dai et al.
Background: Multifactor Dimensionality Reduction (MDR) is a popular and successful data mining method developed to characterize and detect nonlinear complex gene-gene interactions (epistasis) that are associated with dise...
A multilevel layout algorithm for visualizing physical and genetic interaction networks, with emphasis on their modular organization [0.03%]
一种用于可视化物理和遗传相互作用网络的多级布局算法，并着重于它们的模块化组织
Johannes Tuikkala,Heidi Vähämaa,Pekka Salmela et al.
Johannes Tuikkala et al.
Background: Graph drawing is an integral part of many systems biology studies, enabling visual exploration and mining of large-scale biological networks. While a number of layout algorithms are available in popular networ...
Theodoros G Soldatos,Seán I O&#x;Donoghue,Venkata P Satagopam et al.
Theodoros G Soldatos et al.
Background: Keeping up-to-date with bioscience literature is becoming increasingly challenging. Several recent methods help meet this challenge by allowing literature search to be launched based on lists of abstracts that...
Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers [0.03%]
基于结构和序列的分类器组合以改进bevirimat抗性预测
J Nikolaj Dybowski,Mona Riemenschneider,Sascha Hauke et al.
J Nikolaj Dybowski et al.
Background: Maturation inhibitors such as Bevirimat are a new class of antiretroviral drugs that hamper the cleavage of HIV-1 proteins into their functional active forms. They bind to these preproteins and inhibit their c...
Mining the diseasome [0.03%]
采石病典
Davnah Urbach,Jason H Moore
Davnah Urbach