Mining SOM expression portraits: feature selection and integrating concepts of molecular function [0.03%]
基于SOM表达谱系的特征选择及分子功能概念的整合
Henry Wirth,Martin von Bergen,Hans Binder
Henry Wirth
Background: Self organizing maps (SOM) enable the straightforward portraying of high-dimensional data of large sample collections in terms of sample-specific images. The analysis of their texture provides so-called spot-c...
Molecular network analysis of human microRNA targetome: from cancers to Alzheimer's disease [0.03%]
人类microRNA靶向的分子网络分析：从癌症到阿尔茨海默病
Jun-Ichi Satoh
Jun-Ichi Satoh
MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA desta...
GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures [0.03%]
gametes：用于生成纯严格的表型遗传模型的快速直接算法
Ryan J Urbanowicz,Jeff Kiralis,Nicholas A Sinnott-Armstrong et al.
Ryan J Urbanowicz et al.
Background: Geneticists who look beyond single locus disease associations require additional strategies for the detection of complex multi-locus effects. Epistasis, a multi-locus masking effect, presents a particular chal...
Predicting the difficulty of pure, strict, epistatic models: metrics for simulated model selection [0.03%]
纯正且严格的上位模型的难度预测：模拟模型选择指标
Ryan J Urbanowicz,Jeff Kiralis,Jonathan M Fisher et al.
Ryan J Urbanowicz et al.
Background: Algorithms designed to detect complex genetic disease associations are initially evaluated using simulated datasets. Typical evaluations vary constraints that influence the correct detection of underlying mode...
Peer2ref: a peer-reviewer finding web tool that uses author disambiguation [0.03%]
Peer2ref：一种使用作者区分的同行评审员查找网络工具
Miguel A Andrade-Navarro,Gareth A Palidwor,Carol Perez-Iratxeta
Miguel A Andrade-Navarro
Background: Reviewer and editor selection for peer review is getting harder for authors and publishers due to the specialization onto narrower areas of research carried by the progressive growth of the body of knowledge. ...
Vida Abedi,Ramin Zand,Mohammed Yeasin et al.
Vida Abedi et al.
Background: In bio-medicine, exploratory studies and hypothesis generation often begin with researching existing literature to identify a set of factors and their association with diseases, phenotypes, or biological proce...
Finding biomarkers in non-model species: literature mining of transcription factors involved in bovine embryo development [0.03%]
非模型物种中的生物标志物发现：文献挖掘牛胚胎发育中涉及的转录因子
Nicolas Turenne,Evgeniy Tiys,Vladimir Ivanisenko et al.
Nicolas Turenne et al.
Background: Since processes in well-known model organisms have specific features different from those in Bos taurus, the organism under study, a good way to describe gene regulation in ruminant embryos would be a species-...
Sameh Magdeldin,Yutaka Yoshida,Huiping Li et al.
Sameh Magdeldin et al.
Background: Most of the current proteomic researches focus on proteome alteration due to pathological disorders (i.e.: colorectal cancer) rather than normal healthy state when mentioning colon. As a result, there are lack...
Logic minimization and rule extraction for identification of functional sites in molecular sequences [0.03%]
逻辑最小化和规则提取在分子序列功能位点识别中的应用
Raul Cruz-Cano,Mei-Ling Ting Lee,Ming-Ying Leung
Raul Cruz-Cano
Background: Logic minimization is the application of algebraic axioms to a binary dataset with the purpose of reducing the number of digital variables and/or rules needed to express it. Although logic minimization techniq...
Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS [0.03%]
两例全基因组关联研究中散发性ALS成对遗传关联的基因本体分析
Nora Chung Kim,Peter C Andrews,Folkert W Asselbergs et al.
Nora Chung Kim et al.
Background: It is increasingly clear that common human diseases have a complex genetic architecture characterized by both additive and nonadditive genetic effects. The goal of the present study was to determine whether pa...