Optimization and visualization of the edge weights in optimal assignment methods for virtual screening [0.03%]
基于虚拟筛选的最优赋值法中边权重的优化与可视化研究
Lars Rosenbaum,Andreas Jahn,Alexander Dörr et al.
Lars Rosenbaum et al.
Background: Ligand-based virtual screening plays a fundamental part in the early drug discovery stage. In a virtual screening, a chemical library is searched for molecules with similar properties to a query molecule by me...
Using Bayesian networks to discover relations between genes, environment, and disease [0.03%]
应用Bayes网络发现基因、环境和疾病之间的关系
Chengwei Su,Angeline Andrew,Margaret R Karagas et al.
Chengwei Su et al.
We review the applicability of Bayesian networks (BNs) for discovering relations between genes, environment, and disease. By translating probabilistic dependencies among variables into graphical models and vice versa, BNs provide a comprehe...
Genetic variants and their interactions in disease risk prediction - machine learning and network perspectives [0.03%]
机器学习和网络视角下的遗传变异及互作效应在疾病风险预测中的作用
Sebastian Okser,Tapio Pahikkala,Tero Aittokallio
Sebastian Okser
A central challenge in systems biology and medical genetics is to understand how interactions among genetic loci contribute to complex phenotypic traits and human diseases. While most studies have so far relied on statistical modeling and a...
Multifactor dimensionality reduction reveals a three-locus epistatic interaction associated with susceptibility to pulmonary tuberculosis [0.03%]
多因素维度减少法发现了一个与易患肺结核有关的三基因位相互作用
Ryan L Collins,Ting Hu,Christian Wejse et al.
Ryan L Collins et al.
Background: Identifying high-order genetics associations with non-additive (i.e. epistatic) effects in population-based studies of common human diseases is a computational challenge. Multifactor dimensionality reduction (...
Anne Gatewood Hoen,Shea N Gardner,Jason H Moore
Anne Gatewood Hoen
Background: Decades after the eradication of smallpox, its etiological agent, variola virus (VARV), remains a threat as a potential bioweapon. Outbreaks of smallpox around the time of the global eradication effort exhibit...
Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining [0.03%]
利用文献挖掘技术鉴定新的糖皮质激素致胰岛素抵抗作用的生物标志物候选人
Wilco Wm Fleuren,Erik Jm Toonen,Stefan Verhoeven et al.
Wilco Wm Fleuren et al.
Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of...
Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction [0.03%]
基于综合多因子维度降低的多种基因互作风险评分模型
Hongying Dai,Richard J Charnigo,Mara L Becker et al.
Hongying Dai et al.
Background: Multifactor Dimensionality Reduction (MDR) has been widely applied to detect gene-gene (GxG) interactions associated with complex diseases. Existing MDR methods summarize disease risk by a dichotomous predispo...
Multivariate methods and software for association mapping in dose-response genome-wide association studies [0.03%]
剂量反应型全基因组关联研究的多元统计方法及软件包
Chad C Brown,Tammy M Havener,Marisa Wong Medina et al.
Chad C Brown et al.
Background: The large sample sizes, freedom of ethical restrictions and ease of repeated measurements make cytotoxicity assays of immortalized lymphoblastoid cell lines a powerful new in vitro method in pharmacogenomics r...
Application of a spatially-weighted Relief algorithm for ranking genetic predictors of disease [0.03%]
基于地理位置权重的Relief算法在疾病遗传预测因子排名中的应用研究
Matthew E Stokes,Shyam Visweswaran
Matthew E Stokes
Background: Identification of genetic variants that are associated with disease is an important goal in elucidating the genetic causes of diseases. The genetic patterns that are associated with common diseases are complex...
Ignacio González,Kim-Anh Lê Cao,Melissa J Davis et al.
Ignacio González et al.
Background: Each omics platform is now able to generate a large amount of data. Genomics, proteomics, metabolomics, interactomics are compiled at an ever increasing pace and now form a core part of the fundamental systems...