Using random walks to identify cancer-associated modules in expression data [0.03%]
利用随机游走法在基因表达数据中寻找癌症相关模块
Deanna Petrochilos,Ali Shojaie,John Gennari et al.
Deanna Petrochilos et al.
Background: The etiology of cancer involves a complex series of genetic and environmental conditions. To better represent and study the intricate genetics of cancer onset and progression, we construct a network of biologi...
LVQ-SMOTE - Learning Vector Quantization based Synthetic Minority Over-sampling Technique for biomedical data [0.03%]
基于学习向量量化合成少数类过采样技术的LVQ-SMOTE算法用于生物医学数据
Munehiro Nakamura,Yusuke Kajiwara,Atsushi Otsuka et al.
Munehiro Nakamura et al.
Background: Over-sampling methods based on Synthetic Minority Over-sampling Technique (SMOTE) have been proposed for classification problems of imbalanced biomedical data. However, the existing over-sampling methods achie...
gff2sequence, a new user friendly tool for the generation of genomic sequences [0.03%]
用于生成基因组序列的新用户友好型工具GFF2Sequence
Salvatore Camiolo,Andrea Porceddu
Salvatore Camiolo
Background: General Feature Format (GFF) files are used to store genome features such as genes, exons, introns, primary transcripts etc. Although many software packages (i.e. ab initio gene prediction programs) can annota...
The central role of biological data mining in connecting diverse disciplines [0.03%]
生物数据挖掘在连接各学科中的中心作用
Jason H Moore,Marylyn D Ritchie
Jason H Moore
Georgios A Pavlopoulos,Anastasis Oulas,Ernesto Iacucci et al.
Georgios A Pavlopoulos et al.
Elucidating the content of a DNA sequence is critical to deeper understand and decode the genetic information for any biological system. As next generation sequencing (NGS) techniques have become cheaper and more advanced in throughput over...
The disconnect between classical biostatistics and the biological data mining community [0.03%]
经典生物统计学与生物数据挖掘社区之间的脱节
James D Malley,Jason H Moore
James D Malley
MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression [0.03%]
几个脑区中靶基因的微小核糖核酸介导调控与该特定启动子甲基化及微小核糖核酸表达差异相关联
Y-H Taguchi
Y-H Taguchi
Background: Public domain databases nowadays provide multiple layers of genome-wide data e.g., promoter methylation, mRNA expression, and miRNA expression and should enable integrative modeling of the mechanisms of regula...
James D Malley,Abhijit Dasgupta,Jason H Moore
James D Malley
A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection [0.03%]
基于模型的多因素维度减少法检测显性相互作用的参数检验和非参数检验的鲁棒性研究
Jestinah M Mahachie John,François Van Lishout,Elena S Gusareva et al.
Jestinah M Mahachie John et al.
Background: Applying a statistical method implies identifying underlying (model) assumptions and checking their validity in the particular context. One of these contexts is association modeling for epistasis detection. He...
Prediction of Drosophila melanogaster gene function using Support Vector Machines [0.03%]
用支持向量机预测果蝇基因功能
Nicholas Mitsakakis,Zak Razak,Michael Escobar et al.
Nicholas Mitsakakis et al.
Background: While the genomes of hundreds of organisms have been sequenced and good approaches exist for finding protein encoding genes, an important remaining challenge is predicting the functions of the large fraction o...