Sex differences in PD-L1-induced analgesia in paclitaxel-induced peripheral neuropathy mice depend on TRPV1-based inhibition of CGRP [0.03%]
TRPV1介导的CGRP抑制在性激素对紫杉醇诱导的小鼠外周神经病理性疼痛中PD-L1镇痛作用的影响中的作用
Yan Cao,Wenqi Jiang,Fang Yan et al.
Yan Cao et al.
Aims: Paclitaxel (PTX) is extensively utilized in the management of diverse solid tumors, frequently resulting in paclitaxel-induced peripheral neuropathy (PIPN). The present study aimed to investigate sex differences in ...
Building evidence on safety of endovascular thrombectomy for patients under anticoagulation with vitamin K antagonists [0.03%]
维生素K抗凝药抗凝患者的血管内血栓清除术安全性的证据研究
Li Gao,Xiaowei Sun,Peiying Li
Li Gao
A recent study by Brian Mac Grory and colleagues investigated the safety of endovascular thrombectomy (EVT) among patients under vitamin K antagonists (VKAs) use within 7 days prior to hospital admission. Through this retrospective, observa...
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator [0.03%]
重组组织型纤溶酶原激活剂的副作用与中性粒细胞迁移有关
Yuyou Huang,Ziping Han,Tong Shen et al.
Yuyou Huang et al.
Aims: Ischemic stroke remains a challenge in medical research because of the limited treatment options. Recombinant human tissue plasminogen activator (rtPA) is the primary treatment for recanalization. However, nearly 50...
Multicenter integration analysis of TRP channels revealed potential mechanisms of immunosuppressive microenvironment activation and identified a machine learning-derived signature for improving outcomes in gliomas [0.03%]
TRP通道的多中心整合分析揭示了免疫抑制微环境激活的潜在机制，并识别出一种基于机器学习的基因特征以改善胶质瘤预后
Yuntao Li,Yonggang Zhang,Shi Feng et al.
Yuntao Li et al.
Aim: This study aimed to explore the mechanisms of transient receptor potential (TRP) channels on the immune microenvironment and develop a TRP-related signature for predicting prognosis, immunotherapy response, and drug ...
Multicenter Study
CNS neuroscience & therapeutics. 2024 Jul;30(7):e14816. DOI:10.1111/cns.14816 2024
Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study [0.03%]
眼眶和脑联合影像学在甲状腺相关性视神经病变中视神经受压及视觉皮质功能改变中的应用研究
Haiyang Zhang,Yuting Liu,Mengda Jiang et al.
Haiyang Zhang et al.
Aims: To investigate the alterations of the optic nerve and visual cortex in dysthyroid optic neuropathy (DON), a subgroup of thyroid eye disease (TED). M...
The clinical and predictive value of 18F-FDG PET/CT metabolic patterns in a clinical Chinese cohort with autoimmune encephalitis [0.03%]
~临床自身免疫性脑炎患者中18F-FDG PET/CT代谢模式的临床及预测价值
Yuwei Dai,Zehua Zhu,Yongxiang Tang et al.
Yuwei Dai et al.
Aims: To investigate the diagnostic and predictive role of 18F-FDG PET/CT in patients with autoimmune encephalitis (AE) as a whole group. Methods: ...
Neuroimaging and clinical features of bilateral Wallerian degeneration of middle cerebellar peduncles subsequent to pontine infarction [0.03%]
小脑下脚缺血性梗死后的双侧中间梗死半球索瓦勒肯变性的临床及影像学特征分析
Yao Zhang,Ting Wei,Hui Yu et al.
Yao Zhang et al.
Objective: Wallerian degeneration (WD) of the middle cerebellar peduncles (MCPs) following pontine infarction is a rare secondary degenerative neurological condition. Due to its infrequency, there is limited research on i...
GSK3: A potential target and pending issues for treatment of Alzheimer's disease [0.03%]
GSK3：阿尔茨海默病治疗的潜在靶点及待解决问题
Jiahui Zhao,Mengying Wei,Minsong Guo et al.
Jiahui Zhao et al.
Glycogen synthase kinase-3 (GSK3), consisting of GSK3α and GSK3β subtypes, is a complex protein kinase that regulates numerous substrates. Research has observed increased GSK3 expression in the brains of Alzheimer's disease (AD) patients ...
Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults [0.03%]
改良衰弱指数与心脏手术后谵妄的队列研究（2080例老年人）
Hongtao Cheng,Yitong Ling,Qiugui Li et al.
Hongtao Cheng et al.
Aim: To evaluate the association between frailty and postoperative delirium (POD) in elderly cardiac surgery patients. Methods: A retro...
Evidences of neurological injury caused by COVID-19 from glioma tissues and glioma organoids [0.03%]
来自胶质瘤组织和胶质瘤类器官的COVID-19导致神经损伤的证据
Huimin Hu,Chen Wang,Rui Tao et al.
Huimin Hu et al.
Introduction: Despite the extensive neurological symptoms induced by COVID-19 and the identification of SARS-CoV-2 in post-mortem brain samples from COVID-19 patients months after death, the precise mechanisms of SARS-CoV...