Biphasic Memory Impairment and Recovery After Sevoflurane Exposure Are Associated With Time-Dependent Hippocampal α5-GABAAR Remodeling [0.03%]
异氟醚暴露后 biphasic 记忆损伤和恢复与海马α5-GABAAR 时间依赖性重塑有关
Sixuan Wang,Lu Chen,Shengran Wang et al.
Sixuan Wang et al.
Background: Dynamic modulation of α5-GABAAR expression and synaptic distribution plays a pivotal role in neuronal homeostatic plasticity, critically influencing memory processes. This study aims to investigate the spatio...
Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer's Disease [0.03%]
甲硫氨酸、同型半胱氨酸和甲基化水平可预测阿尔茨海默病的认知衰退
Xiaoyu Zhang,Ai Guan,Wanlin Li et al.
Xiaoyu Zhang et al.
Background: Alzheimer's disease (AD), the most common cause of dementia, involves metabolic factors such as homocysteine, methionine, and DNA methylation in its pathogenesis. However, the precise interactions among these ...
Limited Efficacy of 3 mA Intensified tDCS of the Right Inferior Frontal Cortex for OCD Treatment: A Randomized, Double-Blind, Sham-Controlled Study [0.03%]
右侧额下回经颅直流电刺激治疗强迫症的疗效有限：随机双盲对照试验
Atefeh Fatehi-Chenar,Mohsen Dadashi,Alireza Moradi et al.
Atefeh Fatehi-Chenar et al.
Objective: Transcranial direct current stimulation (tDCS) has been proposed for treating obsessive-compulsive disorder (OCD) with advantages such as affordability and home-use application. Despite a moderate therapeutic e...
Randomized Controlled Trial
CNS neuroscience & therapeutics. 2026 May;32(5):e70927. DOI:10.1002/cns.70927 2026
Mettl8 Regulates Hippocampal Neural Stem Cell Proliferation and Neurogenesis via mTOR/4E-BP1 Signaling [0.03%]
Mettl8通过mTOR/4E-BP1信号调节海马神经干细胞增殖和神经发生
Jiamin Xu,Liping Xu,Yang Li et al.
Jiamin Xu et al.
Aims: Hippocampal neural stem cells (NSCs) proliferation and differentiation are crucial for neuroregeneration, but their regulation remains unclear. This study investigates the role of the RNA methyltransferase Mettl8 in...
Polydatin Inhibits Neuroinflammation in Cerebral Ischemia-Reperfusion Injury Through Suppressing the CXCL3/CXCR2 Axis [0.03%]
茋类成分聚茋抑制脑缺血再灌注损伤的神经炎症作用及机制研究
Youxiang Cui,Fangmei Hu,Shixin Wang et al.
Youxiang Cui et al.
Aim: The aim of this study is to investigate the precise mechanisms by which Polydatin (PD) ameliorates cerebral ischemia-reperfusion injury (CIRI). Metho...
Sleep Deprivation Exacerbates Ischemic Stroke Outcomes via Akkermansia Depletion and Metabolic Dysregulation [0.03%]
睡眠剥夺通过Akkermansia减少和代谢失调加重缺血性卒中的后果
Xin Nie,Sheng-Yang Zhou,Le Yao et al.
Xin Nie et al.
Aims: Sleep disturbances are a potential risk factor for stroke. Our clinical cohort shows that insomnia is associated with a higher 90-day stroke recurrence rate, prompting an investigation into the underlying mechanisms...
Stability-Driven Selection of EEG Connectivity Features for Psychosis Classification: A Network-Based Machine Learning Approach [0.03%]
基于网络的机器学习方法驱动下稳定选择精神分裂症分类的EEG连接性特征
Mahdi Naeim,Mohammad Narimani
Mahdi Naeim
Objectives: To develop a network-based machine learning framework for classifying psychosis using EEG connectivity features and to identify stable, reproducible candidate markers through a stability-driven approach. ...
Exercise Effect on Cerebral Artery Hemodynamic and Morphology in Stroke Patients: A Randomized Trial [0.03%]
运动对卒中患者脑动脉血流动力学和形态影响的随机对照试验
Simon Takadiyi Gunda,Ziman Chen,Jerica Hiu-Yui Yip et al.
Simon Takadiyi Gunda et al.
Aims: Stroke is a leading cause of death and disability worldwide and occurs primarily due to impaired cerebrovascular health. Aerobic exercise training (AET) has the potential to improve deconditioned cerebrovascular sta...
Randomized Controlled Trial
CNS neuroscience & therapeutics. 2026 May;32(5):e70942. DOI:10.1002/cns.70942 2026
Tumor Electric Field Therapy Inhibits Epithelial-Mesenchymal Transition, Invasion, and Migration of Glioblastoma by Targeting the c-FOS/CXCL14 Axis [0.03%]
肿瘤电场疗法通过靶向c-FOS/CXCL14轴抑制胶质母细胞瘤的上皮间质转化、侵袭和迁移
Cheng Sun,Yuyang Liu,Junyi Chen et al.
Cheng Sun et al.
Background: Glioblastoma (GBM) is among the most aggressive and treatment-resistant primary brain tumors. The mesenchymal subtype of GBM shows a particularly unfavorable prognosis. Epithelial-mesenchymal transition (EMT) ...
Association Between Differences in Estimated GFR by Creatinine Vs. Cystatin C and Stroke Outcomes: Results From the Third China National Stroke Registry [0.03%]
基于第三中国全国卒中登记队列研究的血清肌酐和胱抑素C估算GFR差值与缺血性卒中的相关性分析
Qi Huang,Yuesong Pan,Hongyi Yan et al.
Qi Huang et al.
Background: The effect of the difference between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRdiff) on stroke outcomes is unclear. This study investigated the association between eGFRdiff an...
Multicenter Study
CNS neuroscience & therapeutics. 2026 May;32(5):e70930. DOI:10.1002/cns.70930 2026