Eplerenone Inhibits Atrial Autonomic Nerve Remodeling in Atrial Fibrillation Through ERK1/2 MAPK Pathway [0.03%]
依普利酮通过ERK1/2 MAPK通路抑制房颤心房自主神经重塑
Wei Xu,Cheng-Yuan Yu,Ding-Yu Wang et al.
Wei Xu et al.
Atrial autonomic nerve system (ANS) remodeling plays an important role in atrial fibrillation (AF). Mineralocorticoid receptor antagonists (MRAs) have been proved to be effective in preventing atrial structural remodeling. However, the effe...
Rivaroxaban Ameliorates Sunitinib-Induced Injury of Cardiomyocytes via Repressing MAPK Signaling Pathway [0.03%]
利伐沙班通过抑制MAPK信号途径改善舒尼替引起的心肌细胞损伤
Ying Qian,Fang Yi
Ying Qian
Background: Sunitinib (SU) is used to treat kidney cancer. However, it can also cause cardiotoxicity. This study is performed to investigate whether rivaroxaban (RIV) attenuates SU-induced cardiotoxicity (SIC). Methods and Materials: AC16 c...
Kynurenic Acid Is a Predictive Prognostic Metabolic Marker in ST-Elevation Myocardial Infarction [0.03%]
代谢标志物夸尼酸能够预测ST段抬高型心肌梗死患者的预后指标
Xiaolin Zhang,Miaohan Qiu,Kun Na et al.
Xiaolin Zhang et al.
Background: The tryptophan/kynurenic acid (KYNA) pathway plays a crucial role by modulating inflammation, oxidative stress, and immune activation. The clinical value of tryptophan metabolites in the KYNA pathway for the early diagnosis and ...
Astragaloside IV Alleviates H2O2-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway [0.03%]
Astragaloside IV缓解H2O2诱导的线粒体功能障碍并通过PI3K / AKT / mTOR途径抑制线粒体自噬
Miaomiao Qi,Qiongying Wang,Runmin Sun et al.
Miaomiao Qi et al.
Oxidative stress and mitochondrial dysfunction play critical roles in the pathology of cardiovascular diseases. However, the effects of Astragaloside IV (As-IV) on mitochondrial function remain unclear. This study is aimed at evaluating the...
Outcomes of 10 mg Rivaroxaban in Nonvalvular Atrial Fibrillation Patients With CrCl ≥ 50 mL/min: A Retrospective Cohort Study [0.03%]
肌酐清除率≥50毫升/分钟的非瓣膜性房颤患者使用利伐沙班（10毫克）的疗效：回顾性队列研究
Qing Yan,Yide Yuan,Jiaqi Liang et al.
Qing Yan et al.
Background: The standard oral dose of rivaroxaban for nonvalvular atrial fibrillation (NVAF) patients with a creatinine clearance rate (CrCl) ≥ 50 mL/min is 20 mg/day in Europe and 15 mg/day in Japan. In the real world, low-dosing (10 mg/d...
Comparative Study
Cardiovascular therapeutics. 2025 Jun 26:2025:7021330. DOI:10.1155/cdr/7021330 2025
Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice [0.03%]
CCr2拮抗剂Propagermanium通过改变巨噬细胞亚群分布促进小鼠心梗后重构
Kay Weipert,Holger Nef,Sandra Voss et al.
Kay Weipert et al.
Aims: The aim of the present study was to investigate the inhibition of classically activated macrophages in myocardial infarction (MI) under the influence of the chemokine (C-C motif) receptor 2 (CCR2) antagonist propagermanium (PPG). Meth...
Trimethylamine-N-Oxide Impedes Late Endothelial Progenitor Cell-Mediated Revascularization by Triggering Mitochondrial Apoptosis via Suppression of MnSOD [0.03%]
N-氧代三甲胺通过抑制MnSOD诱导的线粒体凋亡来阻碍晚期血管生成祖细胞介导的再血管化作用
Yijia Shao,Jiapan Sun,Xiang Liu et al.
Yijia Shao et al.
Background and Aims: Trimethylamine-N-oxide (TMAO) is recognized as a novel marker and mediator of atherosclerotic cardiovascular disease (ASCVD). Endothelial progenitor cells (EPCs) are crucial for maintaining vascular homeostasis. Impaire...
A Meta-Analysis of the Incidence of Adverse Reactions of Statins in Various Diseases [0.03%]
他汀类药物在各种疾病中不良反应的 meta 分析
Wanying Li,Ding Wang,Caiyue Lin et al.
Wanying Li et al.
Introduction: In clinical practice, patients often avoid or cease statin use due to adverse reactions or noncompliance. To elucidate statin adverse reactions, their variability across diseases, and the factors influencing them, we conducted...
Exploring the Mechanism of Action of Berberine on Arrhythmia After Myocardial Infarction: A Network Pharmacology, Molecular Docking, and Cellular Experimental Study [0.03%]
网络药理学、分子对接及细胞实验联合研究黄连素对心肌梗死后心律失常作用机制研究
Haitian-Li,Zhijie-Zhang,Yang-Yang et al.
Haitian-Li et al.
Background: Arrhythmia after myocardial infarction, a common disease, has a high incidence and lethality in clinical practice, which seriously affects patients' quality of life and survival time. Based on our previous study and available ev...
The Effect of Vasopressin on 90-Day Mortality in Patients With Cardiogenic Shock: A Retrospective Cohort Study Using Propensity Score-Weighted Analysis [0.03%]
抗利尿激素对心源性休克患者90天死亡率的影响：倾向得分类权重分析的回顾队列研究
Christophe Beyls,Thomas Hanquiez,Nicolas Mollet et al.
Christophe Beyls et al.
Background: Cardiogenic shock (CS) may lead to a refractory vasoplegic state that requires vasopressin on top of norepinephrine. Vasopressin has been available in France since January 2022. However, data assessing the clinical impact of vas...