Acceptability of and satisfaction with continuous glucose monitoring in pregnant women with type 2 diabetes mellitus: A service improvement project [0.03%]
连续血糖监测在2型糖尿病孕产妇中的接受度及满意度：一种服务质量改进项目
Sridevi Beriwal,Federica Re,Sharon Gibson et al.
Sridevi Beriwal et al.
Background: There are limited data regarding intermittently scanned continuous glucose monitoring (isCGM) in pregnancy for women with Type 2 diabetes. We have tested the acceptability and feasibility of an isCGM method us...
Meta-analyses in cholestatic pregnancy: The outstanding clinical questions [0.03%]
妊娠胆汁淤积症的meta分析：亟待解决的临床问题
Nadejda Capatina,Caroline Ovadia
Nadejda Capatina
Reports of adverse pregnancy outcomes associated with maternal pruritus and liver impairment have circulated since the 1800s, yet the precise diagnosis and management of intrahepatic cholestasis of pregnancy have varied markedly. Recent evi...
Genetic issues in ICP [0.03%]
ICP的遗传问题
Julia Zöllner,Catherine Williamson,Peter H Dixon
Julia Zöllner
Intrahepatic cholestasis of pregnancy (ICP) is the commonest gestational liver disorder with variable global incidence. Genetic susceptibility, combined with hormonal and environmental influences, contributes to ICP aetiology. Adverse pregn...
Corey Markus,Wm Bill Hague
Corey Markus
In this paper, we discuss the Bile Acid Comparison and Harmonisation project, a sub-study of the Trial of URsodeoxycholic acid vs RIFampicin in early-onset severe Intrahepatic Cholestasis of pregnancy, giving an overview of the current stat...
Microbial metabolites as a way to provide crosstalk between gut and liver [0.03%]
肠道微生物代谢产物——肠道与肝脏串话的媒介
Marloes Dekker Nitert,Caroline Ovadia
Marloes Dekker Nitert
Bile acid metabolism is partially regulated through the activity of the gut microbiota. Primary bile acids can be deconjugated and modified by bacteria expressing bile salt hydrolase and other enzymes, changing bile acid recycling by changi...
Zivile Useckaite
Zivile Useckaite
Extracellular vesicles (EVs) are small, nonreplicating, lipid-encapsulated nanoparticles that carry protein and nucleic acid cargo derived from their tissue of origin. Due to their capacity to provide comparable insights to solid organ biop...
Intrahepatic cholestasis of pregnancy: Introduction and overview 2024 [0.03%]
妊娠期肝内胆汁淤积症：介绍与概述（2024年更新）
Wm Bill Hague,Catherine Williamson,Ulrich Beuers
Wm Bill Hague
Considerable progress has been made to explain the aetiology of intrahepatic cholestasis of pregnancy (ICP) and of the adverse pregnancy outcomes associated with high maternal total serum bile acids (TSBAs). The reported thresholds for non-...
Jenny Chambers
Jenny Chambers
Through their personal experience of having intrahepatic cholestasis of pregnancy (ICP), this paper covers the development of current understanding of ICP. It summarises how research and clinical practice was developed through clinicians an...
Sarah K Giles,Wm Bill Hague,Robert A Edwards
Sarah K Giles
Intrahepatic cholestasis of pregnancy (ICP) is the most common liver-specific disorder affecting pregnant women, with an Australian incidence of 0.6% pa and recurring in 70% of those affected. ICP causes mild to severe pruritus, often resul...