Yves Ozier,Lorenn Bellamy
Yves Ozier
This article provides an overview of the scientific evidence regarding the efficacy and safety of antifibrinolytic agents and desmopressin to reduce surgical blood loss. The synthetic derivatives of lysine are the only antifibrinolytics ava...
Oliver Grottke,Dietrich Henzler,Rolf Rossaint
Oliver Grottke
Recombinant activated factor VII (rFVIIa) is a haemostatic agent, which was originally developed for the treatment of haemophilia patients with inhibitors against factor FVIII or FIX. The efficacy of rFVIIa in preventing or stopping life-th...
Wolfgang Korte
Wolfgang Korte
Unexplained intra-operative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intra-operative coagulopathies is of great variety and complexity (pre-existing coagulopathies, dilutiona...
Platelet transfusions: the science behind safety, risks and appropriate applications [0.03%]
血小板输注：安全、风险及适宜应用的相关研究
Bruce D Spiess
Bruce D Spiess
Platelets are active metabolising cells that are evolved for the tasks of haemostasis, inflammatory reactions and wound healing. When platelet products are stored in the blood bank a complex series of changes occur, leading to partial activ...
Daryl J Kor,James R Stubbs,Ognjen Gajic
Daryl J Kor
Clinical studies support the use of perioperative fresh frozen plasma (FFP) in patients who are actively bleeding with multiple coagulation factor deficiencies and for the prevention of dilutional coagulopathy in patients with major trauma ...
Pierre Albaladejo,Charles Marc Samama
Pierre Albaladejo
Interruption or maintenance of anti-platelet agents (APAs) during surgical or invasive procedures is associated with an increase in cardiovascular or haemorrhagic complications, respectively. The pharmacology and indications of aspirin, clo...
Sibylle A Kozek-Langenecker
Sibylle A Kozek-Langenecker
Perioperative coagulation monitoring is the rational diagnostic basis for pro- and anti-thrombotic interventions in patients undergoing emergency and elective surgery. The main goal of perioperative monitoring of haemostasis is to increase ...
Michael T Ganter,Jean-François Pittet
Michael T Ganter
Abnormal coagulation parameters can be found in 25% of trauma patients with major injuries. Furthermore, trauma patients presenting with coagulopathy on admission have worse clinical outcome. Tissue trauma and systemic hypoperfusion appear ...
Petra Innerhofer,Joachim Kienast
Petra Innerhofer
Perioperative coagulopathy impacts on patient outcome by influencing final blood loss and transfusion requirements. The recognition of pre-existing disturbances and the basic understanding of the principles of and dynamic changes of haemost...
Michael T Ganter,Donat R Spahn
Michael T Ganter