S Jack,M West,M P W Grocott
S Jack
The association between physical fitness and outcome following major surgery is well described - less fit patients having a higher incidence of perioperative morbidity and mortality. This has led to the idea of physical training (exercise t...
William Silvester,Karen Detering
William Silvester
It is ethically and legally important, when providing care to our patients, to respect their autonomy and dignity, to act in their best interests and avoid doing harm. Advance care planning is essential to achieving this by giving patients ...
Robert C McDermid,Sean M Bagshaw
Robert C McDermid
Average life expectancy has increased over the past century resulting in a shift in world population demographics. There are more elderly people alive now than throughout all of human history. The burden of comorbid disease and dependency r...
M West,S Jack,M P W Grocott
M West
The elderly constitute an increasingly large segment of the population and of the patients requiring medical attention. Major surgery is associated with a substantial burden of postoperative morbidity and mortality. Advancing age is a parti...
Emily G Y Koo,Linda M L Lai,Gordon Y S Choi et al.
Emily G Y Koo et al.
Inflammation is an adaptive response to surgery. When the pro-inflammatory responses are unregulated and become over reactive, systemic inflammatory response syndrome may occur. Postoperative systemic inflammation is more common than is gen...
Michael Haase,David A Story,Anja Haase-Fielitz
Michael Haase
Acute kidney injury (AKI) in the elderly patient is a common iatrogenic complication of major surgery that impacts morbidity, mortality and resource use. Several renal functional and structural changes have been described, including a subst...
Hypoalbuminaemia in the perioperative period: clinical significance and management options [0.03%]
围术期低白蛋白血症的临床意义及处理选择
Dustin R Neel,Stephen McClave,Robert Martindale
Dustin R Neel
Albumin has been the focus of literally thousands of articles since its first use in the clinical setting during World War II. Despite being at the centre of several clinical controversies, many questions still remain regarding the use and ...
Brendan Silbert,Lisbeth Evered,David A Scott
Brendan Silbert
Postoperative cognitive dysfunction (POCD) was originally thought to be associated with cardiac surgery, but has since been associated with non-cardiac surgery and even sedation for non-invasive procedures such as coronary angiography. The ...
Julia C Coldrey,Richard N Upton,Pamela E Macintyre
Julia C Coldrey
The average age of the world's population is increasing rapidly, with those over 80 years of age the fastest growing subsection of older persons. Consequently, a higher proportion of those presenting for surgery in the future will be older,...
Martijn R Kruijt Spanjer,Nicolaas A Bakker,Anthony R Absalom
Martijn R Kruijt Spanjer
In developed countries, a growing proportion of patients presenting for anesthesia and surgery are elderly. Despite this, and the fact that aging is known to be associated with alterations in drug pharmacokinetics and dynamics, there is lit...