Andrew Padkin
Andrew Padkin
This article presents a template for judging trials of tight glucose control in critically ill patients. It reviews threats to both internal validity and generalisability using examples from the current literature. When judging internal val...
Thomas Duning,Björn Ellger
Thomas Duning
Tight glycaemic control (TGC) for patients treated in an intensive care unit ICU is associated with an increased risk for hypoglycaemia. Since hypoglycaemia mainly occurs in the sickest patients, no matter whether TGC is applied or not, it ...
Frank Nobels,Patrick Lecomte,Natascha Deprez et al.
Frank Nobels et al.
Implementation of tight glycaemic control in hospitalised patients presents a huge challenge. It concerns many patients, there are many interfering factors and many health-care professionals are involved. The current literature provides lit...
Molecular mechanisms behind clinical benefits of intensive insulin therapy during critical illness: glucose versus insulin [0.03%]
危重症状态下强化胰岛素治疗的临床效益背后的分子机制：血糖与胰岛素
Ilse Vanhorebeek,Lies Langouche
Ilse Vanhorebeek
High blood glucose levels have been associated with morbidity and poor outcome in critically ill patients, irrespective of underlying pathology. In a large, randomised, controlled study the use of insulin therapy to maintain normoglycaemia ...
Clinical benefits of tight glycaemic control: focus on the paediatric patient [0.03%]
严密血糖控制的临床优势：以儿科患者为重点
Ingeborg van den Heuvel,Dirk Vlasselaers
Ingeborg van den Heuvel
Hyperglycaemia and glucose variability occur frequently during critical illness or after major surgery in children and are associated with worse outcome. Association does not necessarily imply causality however, and the question whether tig...
Jan Gunst,Miet Schetz
Jan Gunst
Acute kidney injury is a frequent and life-threatening complication of critical illness. Prevention of this condition is crucial. Two randomized single center trials in critically ill patients have shown a decrease in acute kidney injury by...
Clinical benefits of tight glycaemic control: focus on the intensive care unit [0.03%]
严密血糖控制的临床优势：重点集中在重症监护病房
Dieter Mesotten,Greet Van den Berghe
Dieter Mesotten
While stress hyperglycaemia has traditionally been regarded as an adaptive, beneficial response, it is clear that hyperglycaemia and hypoglycaemia are associated with increased risk of death in critically ill intensive care unit (ICU) patie...
Clinical benefits of tight glycaemic control: focus on the perioperative setting [0.03%]
严密血糖控制的临床益处：以围手术期为重点
Anthony P Furnary
Anthony P Furnary
The benefits of tight glycaemic control (TGC) were first shown in cardiac surgical patients with diabetes. These concepts migrated to other surgical and medical specialties through intensive care units caring for a variety of patients with ...
Modulating postoperative insulin resistance by preoperative carbohydrate loading [0.03%]
术前碳水化合物负荷调节术后胰岛素抵抗
Olle Ljungqvist
Olle Ljungqvist
The concept of preoperative overnight fasting was challenged and proved to have no benefits over allowing patients to drink clear fluids up until 2 h before surgery. This led to changes in the guidelines for preoperative fasting in many cou...
How accurately do we measure blood glucose levels in intensive care unit (ICU) patients? [0.03%]
我们如何准确测量重症监护病房(ICU)患者的血糖水平？
Hans Günther Wahl
Hans Günther Wahl
Hyperglycaemia is commonly found in critically ill patients as a result of numerous processes such as increased gluconeogenesis and glycogenolysis caused by elevated levels of corresponding hormones and insulin resistance. As the clinical c...