Is glycaemia or insulin dose the stronger risk factor for coronary artery disease in type 1 diabetes? [0.03%]
1型糖尿病患者中血糖控制与胰岛素剂量哪个是冠心病更强的风险因素？
Baqiyyah Conway,Tina Costacou,Trevor Orchard
Baqiyyah Conway
Although coronary artery disease (CAD) is the leading cause of death in type 1 diabetes (T1D), the mechanisms responsible for the greatly increased risk are poorly understood. In particular, the role of glycaemic control is controversial wi...
Drazenka Pongrac Barlovic,Mark E Cooper
Drazenka Pongrac Barlovic
Efficacy and safety of muraglitazar: a double-blind, 24-week, dose-ranging study in patients with type 2 diabetes [0.03%]
孟拉格列扎片的疗效和安全性：2型糖尿病患者的双盲、24周剂量范围研究
Cindy J Rubin,Kalyanee Viraswami-Appanna,Fred T Fiedorek
Cindy J Rubin
Muraglitazar is a dual (alpha/gamma) PPAR activator. Dual receptor activation may improve glycaemic and lipid profiles in patients with type 2 diabetes mellitus.This randomised double-blind trial in 1,477 drug-naive patients with type 2 dia...
Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus [0.03%]
葡萄籽提取物的抗氧化作用的糖尿病大鼠模型研究
Irina C Chis,Marius I Ungureanu,Adriana Marton et al.
Irina C Chis et al.
In the present study we investigated the anti-hyperglycaemic and antioxidant effect of grape seed extract, a polyphenolic flavonoid, in normal and streptozotocin-induced diabetic Wistar rats. Adult male Wistar rats were divided into three g...
Hypovitaminosis D in Chinese type 2 diabetes: lack of impact on clinical metabolic status and biomarkers of cellular inflammation [0.03%]
维生素D缺乏对中国2型糖尿病临床代谢状态及细胞炎症生物标志物的影响
C Luo,J Wong,M Brown et al.
C Luo et al.
Objective: Low vitamin D (25 OH vitamin D) is implicated in the development of diabetes and the metabolic syndrome. We examined whether hypovitaminosis D has a clinically significant impact on glycaemia, metabolic status ...
Raised natriuretic peptides, big-endothelin-1 and improved beta-cell function in type 2 diabetic males with hyperuricaemia [0.03%]
高尿酸血症Ⅱ型糖尿病男性患者脑利钠肽、大内皮素-1及β细胞功能改善
Michel P Hermans,Sylvie A Ahn,Michel F Rousseau
Michel P Hermans
Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. We characterised the associations between neurohormones, uricaemia, and glucose...
Kunihiko Aizawa,J Kevin Shoemaker,Tom J Overend et al.
Kunihiko Aizawa et al.
We evaluated (1) endothelial function (FMD, ICAM-1 and VCAM-1) cross-sectionally in subjects with (MS+) and without (MS-) metabolic syndrome who were at increased risk for cardiovascular disease due to either HNBP and/or IGR, and (2) examin...
Review article: Diabetes mellitus and heart failure--an overview of epidemiology and management [0.03%]
糖尿病与心力衰竭——流行病学及治疗概述
V Baliga,R Sapsford
V Baliga
Heart failure and diabetes mellitus are chronic complex medical conditions that are closely related and commonly coexist.Treatment options have varied over the years, but newer treatment modalities have developed which have improved prognos...
Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease--do we need to screen our patients? [0.03%]
评述：代谢综合征与糖尿病患者的心力衰竭和左心室功能障碍——对无明显冠状动脉疾病的患者进行筛查有必要吗？
Aled W Roberts,Andrew L Clark,Klaus K Witte
Aled W Roberts
The metabolic syndrome and its components, glucose intolerance, T2DM, hypertension, dyslipidaemia and obesity are increasingly common. Patients with the metabolic syndrome have a higher prevalence of chronic heart failure (CHF) and, once di...
Parminder S Chaggar,Steven M Shaw,Simon G Williams
Parminder S Chaggar
DM is an independent risk factor for the development of HF and its presence confers an adverse prognosis for those already diagnosed with HF.TZDs are potent insulin-sensitisers associated with a number of beneficial cardiovascular effects. ...