Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans [0.03%]
人弹性动脉中可能有重要的甲基乙二醛衍生AGE修饰目标——纤溶酶原
Terje Lund,Aud Svindland,Milaim Pepaj et al.
Terje Lund et al.
Diabetes is associated with increased risk of cardiovascular disease. Advanced glycation end-products (AGEs) are considered to be a major pathogenic factor for diabetic vascular complications. The levels of AGEs are increased in diabetic pa...
Effects of human endothelial gene polymorphisms on cellular responses to hyperglycaemia: role of NOS3 (Glu298Asp) and ACE (I/D) polymorphisms [0.03%]
内皮细胞NOS3(Glu298Asp)和ACE(I/D)基因多态性对高糖刺激反应的影响研究
Mandar S Joshi,Suvara Wattanapitayakul,Brandon L Schanbacher et al.
Mandar S Joshi et al.
The functional relevance of NOS3 and ACE genetic variations to endothelial cell function is largely unstudied. Here we tested the functional relevance of the NOS3 (Glu298Asp) polymorphism and ACE (I/D) polymorphism in endothelial cells in v...
The long and winding road [0.03%]
漫长而曲折的道路
Peter J Grant
Peter J Grant
Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients [0.03%]
血白细胞的炎症效应：与神经肽Y第7位脯氨酸基因型2型糖尿病患者的血管功能的关系
Tanja Kakko,Ulriikka Jaakkola,Olli T Raitakari et al.
Tanja Kakko et al.
Objective: We investigated the associations of inflammatory blood cell activation with vascular parameters in patients with type 2 diabetes to elucidate the possible mechanisms of accelerated atherosclerosis observed in s...
Factors influencing endothelial function in healthy pre- and post-menopausal women of the EU-RISC study [0.03%]
欧盟RISC研究中影响健康绝经前和绝经过后妇女内皮功能的因素
Thomas Konrad,Frances Bär,Frank Schneider et al.
Thomas Konrad et al.
Background: We studied the impact of lifestyle, body composition, different insulin sensitivity indices and the first insulin response in healthy pre- and post-menopausal women with a low cardiovascular risk profile (the ...
Multicenter Study
Diabetes & vascular disease research. 2011 Jul;8(3):229-36. DOI:10.1177/1479164111416139 2011
Impaired microvascular properties in uncomplicated type 1 diabetes identified by Doppler ultrasound of the ocular circulation [0.03%]
利用多普勒超声心动图识别的1型糖尿病患者的微血管异常
Christopher J Lockhart,Aaron McCann,Christina A Agnew et al.
Christopher J Lockhart et al.
Objective: Quantification of Doppler flow velocity waveforms has been shown to predict adverse cardiovascular outcomes and identify altered downstream haemodynamics and vascular damage in a number of organ beds. We employ...
Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2: 3 liraglutide clinical development studies [0.03%]
利拉鲁肽心血管安全性的患者层面汇总分析：来自2-3期临床研究的数据
Steven P Marso,Jason B Lindsey,Joshua M Stolker et al.
Steven P Marso et al.
We assessed the cardiovascular safety of liraglutide, a glucagon-like peptide-1 receptor agonist, using existing clinical data. Patient-level results from all completed phase 2 and 3 studies from the liraglutide clinical development program...
Circulating endothelial progenitor cells in women with gestational alterations of glucose tolerance [0.03%]
糖耐量异常孕妇的循环内皮祖细胞
Giuseppe Penno,Laura Pucci,Daniela Lucchesi et al.
Giuseppe Penno et al.
Endothelial progenitor cells (EPCs) play a role in angiogenesis during pregnancy. The aim of this study was to evaluate circulating EPCs in pregnant women with gestational alterations of glucose tolerance. Glucose tolerance, insulin sensiti...
Rosiglitazone improves endothelial function in patients with type 2 diabetes treated with insulin [0.03%]
罗格列酮改善胰岛素治疗的2型糖尿病患者的内皮功能
Katerina K Naka,Katerina Papathanassiou,Aris Bechlioulis et al.
Katerina K Naka et al.
An increased incidence of myocardial infarction with rosiglitazone in patients with type 2 diabetes mellitus (T2DM) has been reported. This study aimed to assess the effect of rosiglitazone on endothelial function, assessed by flow-mediated...
Randomized Controlled Trial
Diabetes & vascular disease research. 2011 Jul;8(3):195-201. DOI:10.1177/1479164111408628 2011
Non-invited review: prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD [0.03%]
非邀请述评：来自FIELD和ACCORD研究的启示：非诺贝特预防糖尿病微血管并发症的作用
Michel P Hermans
Michel P Hermans
Microvascular complications are common in type 2 diabetes in primary care. Intensified management of glycaemia or blood pressure had little effect on microvascular complication rates in recent large trials (ADVANCE, VADT, ACCORD). In 2005, ...