David R Matthews
David R Matthews
Peroxisome proliferator-activated receptor (PPAR α/γ) agonists as a potential target to reduce cardiovascular risk in diabetes [0.03%]
糖尿病患者心血管风险(peroxisome proliferator-activated receptor(PPAR α/γ)激动剂的作用及作用机制）
Stephen J Nicholls,Kiyoko Uno
Stephen J Nicholls
The disappointing results of glucose lowering studies have highlighted the ongoing need to develop new therapeutic strategies to reduce cardiovascular risk in patients with type 2 diabetes. The presence of a range of metabolic abnormalities...
Dipeptidyl peptidase-IV is a potential molecular biomarker in diabetic kidney disease [0.03%]
二肽基肽酶-IV是糖尿病肾脏疾病的潜在分子生物标志物
Ai-li Sun,Jing-ti Deng,Guang-ju Guan et al.
Ai-li Sun et al.
The present study was designed to identify the changes in microvesicle-dipeptidyl peptidase-IV (DPP IV) levels in human urine and serum, and to determine whether there were correlations with the severity of diabetic kidney disease (DKD). A ...
Celine Foote,Vlado Perkovic,Bruce Neal
Celine Foote
Glucose in the glomerular ultrafiltrate is actively reabsorbed by sodium glucose transporters (SGLT) in the proximal tubule. The SGLT2 protein is a high capacity molecule responsible for the majority of glucose reuptake with pharmacological...
Global cardiovascular disease risk assessment in United States adults with diabetes [0.03%]
美国成年人糖尿病患者的心血管疾病风险评估
Nathan D Wong,Diana Glovaci,Kalina Wong et al.
Nathan D Wong et al.
Background: Diabetes mellitus (DM) is often considered a risk equivalent for cardiovascular disease (CVD); however, the variation in CVD risk in adults with DM has not been described. ...
Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: a report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study [0.03%]
糖尿病血糖控制对皮肤微循环的影响：来自糖尿病和舒张期心力衰竭（DADD）研究的报告
Christina Jarnert,Majid Kalani,Lars Rydén et al.
Christina Jarnert et al.
Background: Microcirculatory and endothelial dysfunction are signs of cardiovascular engagement in patients with type 2 diabetes. This study tested whether glucose normalisation may reverse this. ...
Randomized Controlled Trial
Diabetes & vascular disease research. 2012 Oct;9(4):287-95. DOI:10.1177/1479164111432182 2012
Tessey Jose,Silvio E Inzucchi
Tessey Jose
Type 2 Diabetes continues to rise in prevalence throughout the globe, and cardiovascular diseases remain the most common cause of morbidity and mortality among patients. Dipeptidyl-peptidase-4 (DPP-4) inhibitors are a newer class of oral an...
Soluble RAGE and malondialdehyde in type 1 diabetes patients without chronic complications during the course of the disease [0.03%]
无慢性并发症的1型糖尿病患者疾病过程中的可溶性RAGE和丙酮酸甲醛基胩水平
Janice S Reis,Clara A Veloso,Caroline M O Volpe et al.
Janice S Reis et al.
Malondialdehyde (MDA), an end product of lipid peroxidation and biomarker for oxidative stress, and its soluble receptor (sRAGE) were evaluated in 42 patients with type 1 diabetes mellitus, but without chronic complications, during the earl...
Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: the effect of diabetes [0.03%]
糖尿病对体外循环大鼠肠系膜内皮功能障碍的影响研究
Vincent Le Guillou,Fabienne Tamion,Isabelle Jouet et al.
Vincent Le Guillou et al.
Background: Diabetes is a risk factor for perioperative complications after cardiac surgery. We studied its effects on mesenteric endothelial function in a cardiopulmonary bypass (CPB) model. ...
Body mass index and waist circumference associate to a comparable degree with insulin resistance and related metabolic abnormalities in South Asian women and men [0.03%]
体质指数和腰围与南亚女性和男性的胰岛素抵抗及相关代谢异常的关系程度相当
Fahim Abbasi,Donna Malhotra,Ashish Mathur et al.
Fahim Abbasi et al.
Aim: The aim of this study was to test the hypothesis that body mass index (BMI) and waist circumference (WC) associate to a comparable degree with insulin resistance and cardiometabolic risk factors in South Asians. ...