Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trial [0.03%]
针对2型糖尿病的磺脲类药物心血管结局争议及卡罗琳亚研究合理性
Julio Rosenstock,Nikolaus Marx,Steven E Kahn et al.
Julio Rosenstock et al.
Sulphonylureas (SUs) are widely used glucose-lowering agents in type 2 diabetes mellitus (T2DM) with apparent declining efficacy over time. Concerns have been raised from observational retrospective studies on the cardiovascular (CV) safety...
Sanna M M Heikkinen,Janne M Pitkäniemi,Maritta L Kilpeläinen et al.
Sanna M M Heikkinen et al.
Aims/hypothesis: Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of ch...
Is there benefit in dual renin-angiotensin-aldosterone system blockade? No, yes and maybe: a guide for the perplexed [0.03%]
双重肾素-血管紧张素-醛固酮系统阻断有好处吗？没有、有和可能：困惑者的指南
Jencia Wong
Jencia Wong
Since the initial discovery of Angiotensin converting enzyme inhibitors (ACEI) in the 1960s and the launch of Captopril as the first available for clinical use in the 1970s, there now exist three other classes of drugs that block the renin ...
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology [0.03%]
糖尿病与缺血性和非缺血性慢性心力衰竭的不良预后相关
Richard M Cubbon,Brook Adams,Adil Rajwani et al.
Richard M Cubbon et al.
Background: It is unclear whether diabetes mellitus (DM) is an adverse prognostic factor in chronic heart failure (CHF) of ischaemic and non-ischaemic aetiology managed with contemporary evidence-based care. ...
Association of sulphonylurea treatment with all-cause and cardiovascular mortality: a systematic review and meta-analysis of observational studies [0.03%]
磺脲类药物治疗与全因和心血管死亡率的关联：观察性研究的系统评价和meta分析
Thomas Forst,Markolf Hanefeld,Stephan Jacob et al.
Thomas Forst et al.
We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other d...
Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study [0.03%]
Tehran Lipid and Glucose研究中血糖升高与心血管事件的关系
Maryam Barzin,Farhad Hosseinpanah,Ramin Malboosbaf et al.
Maryam Barzin et al.
Objective: To evaluate the risk of cardiovascular events in diabetes defined by isolated post-challenge hyperglycaemia (IPH). Methods: ...
A comparison of efficacy and safety of an ezetimibe/simvastatin combination compared with other intensified lipid-lowering treatment strategies in diabetic patients with symptomatic cardiovascular disease [0.03%]
依折麦布/辛伐他汀复方与其它强化降脂治疗策略在糖尿病合并心血管病患者中的疗效及安全性比较研究
Jeffrey B Rosen,Jose G Jimenez,Valdis Pirags et al.
Jeffrey B Rosen et al.
The low-density lipoprotein cholesterol (LDL-C) lowering efficacy of switching to ezetimibe/simvastatin (EZ/S) 10/20 mg versus doubling the run-in statin dose (to simvastatin 40 mg or atorvastatin 20 mg) or switching to rosuvastatin 10 mg i...
Randomized Controlled Trial
Diabetes & vascular disease research. 2013 May;10(3):277-86. DOI:10.1177/1479164112465212 2013
Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin at high risk of metabolic syndrome [0.03%]
在南亚、非洲加勒比和白人欧洲成人中关于高代谢风险的β细胞功能、膳食摄入及代谢综合征的表达的族裔差异性研究
Louise M Goff,Bruce A Griffin,Julie A Lovegrove et al.
Louise M Goff et al.
A cross-sectional analysis of ethnic differences in dietary intake, insulin sensitivity and beta-cell function, using the intravenous glucose tolerance test (IVGTT), was conducted on 497 healthy adult participants of the 'Reading, Imperial,...
Aftab Ahmad,Prakash Paliwal,Benjamin R Wakerley et al.
Aftab Ahmad et al.
Hemichorea, due to contralateral basal ganglia dysfunction, is well described in patients with hyperglycaemia but the underlying mechanism remains poorly understood. We present clinical and radiological data that support ipsilateral vascula...
Microcirculatory vasomotor changes are associated with severity of peripheral neuropathy in patients with type 2 diabetes [0.03%]
微循环血管运动变化与2型糖尿病周围神经病变严重程度相关性研究
Pi-Chang Sun,Cheng-Deng Kuo,Lin-Yang Chi et al.
Pi-Chang Sun et al.
Systemic microvascular complications are related to the presence of diabetic neuropathy. This study investigated the associations of blood flow oscillations with peripheral neuropathy in 25 controls and 3 diabetic groups including clinical ...