Testosterone and sex hormone-binding globulin in dysglycemic women at high cardiovascular risk: A report from the Outcome Reduction with an Initial Glargine Intervention trial [0.03%]
性别二酰基甘油风险高的糖尿病妇女中的睾丸素与性激素结合球蛋白：来自初始格拉汀干预试验Outcome Reduction的报道
Anne Wang,Hertzel C Gerstein,Shun Fu Lee et al.
Anne Wang et al.
Aims: Total and free testosterone and sex hormone-binding globulin may affect cardiovascular prognosis in women. The objective was to study the association between sex hormones and prognosis in women with dysglycemia and ...
Randomized Controlled Trial
Diabetes & vascular disease research. 2021 Mar-Apr;18(2):14791641211002475. DOI:10.1177/14791641211002475 2021
Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb [0.03%]
内皮细胞PKCδ敲除预防VEGF抑制并恢复糖尿病缺血性肢体再灌注血液流动
Laura Croteau,Clément Mercier,Étienne Fafard-Couture et al.
Laura Croteau et al.
Aims: Peripheral artery disease is a complication of diabetes leading to critical hindlimb ischemia. Diabetes-induced inhibition of VEGF actions is associated with the activation of protein kinase Cδ (PKCδ). We aim to s...
Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals [0.03%]
糖尿病和健康个体中单核细胞的胰岛素敏感性随年龄下降
Suguru Nakamura,Kentaro Mori,Hideyuki Okuma et al.
Suguru Nakamura et al.
Objective: It is unclear whether monocyte/macrophage insulin signaling in humans is affected by type 2 diabetes (T2DM), systemic insulin sensitivity, and other unknown factors. ...
Effect of sotagliflozin as an adjunct to insulin therapy on blood pressure and arterial stiffness in adults with type 1 diabetes: A post hoc pooled analysis of inTandem1 and inTandem2 [0.03%]
Sotagliflozin辅助胰岛素治疗对1型糖尿病成人血压和动脉僵硬度的影响：inTandem1和inTandem2研究的事后汇总分析
Helena W Rodbard,Andrea Giaccari,Bertrand Cariou et al.
Helena W Rodbard et al.
Objective: Evaluate the effect of sotagliflozin, a dual inhibitor of sodium glucose cotransporter (SGLT) 1 and 2, on arterial stiffness in patients with type 1 diabetes (T1D) treated with sotagliflozin as adjunct to optim...
Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study [0.03%]
糖尿病、性别和慢性心力衰竭患者的估计肾小球滤过率恶化：10年前瞻性队列研究
Jessica Kearney,Michael Drozd,Andrew Mn Walker et al.
Jessica Kearney et al.
Introduction: We aimed to evaluate the relationship between temporal changes in renal function and long-term mortality in patients with heart failure with reduced ejection fraction (HFrEF) and identify correlates of deter...
Vascular inflammation, atherosclerosis, and lipid metabolism and the occurrence of non-high albuminuria diabetic kidney disease: A cross-sectional study [0.03%]
血管炎症、动脉粥样硬化和脂代谢与非高白蛋白尿糖尿病肾病发生的关系：横断面研究
Yuwei Yang,Peng Xu,Yan Liu et al.
Yuwei Yang et al.
Aim: Atherosclerosis involves vascular endothelial damage and lipid metabolism disorder, which is closely related to the occurrence and development of diabetic kidney disease (DKD). However, studies on non-high albuminuri...
Hyperglycemia compromises the ischemia-provoked dedifferentiation of cerebral pericytes through p21-SOX2 signaling in high-fat diet-induced murine model [0.03%]
高脂饮食诱导的小鼠模型中的高血糖通过p21-SOX2信号通路损害脑周细胞缺血诱发的去分化现象
Hao-Kuang Wang,Chih-Yuan Huang,Yun-Wen Chen et al.
Hao-Kuang Wang et al.
Aim: Diabetes-related cerebral small vessel disease (CSVD) causes neurological deficits. Patients with diabetes showed pericyte loss as a hallmark of retinopathy. Cerebral pericytes, which densely localize around brain ca...
DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice [0.03%]
一种针对晚期糖基化末端产物受体的DNA适配体能够抑制糖尿病小鼠肾小管损伤并改善胰岛素抵抗作用
Ami Sotokawauchi,Takanori Matsui,Yuichiro Higashimoto et al.
Ami Sotokawauchi et al.
Objective: Interaction of advanced glycation end products (AGEs) with the receptor RAGE plays a role in diabetic nephropathy. However, effects of RAGE-aptamer on tubular damage remain unknown. We examined whether RAGE-apt...
Prediabetes versus type 2 diabetes mellitus based on pre-percutaneous coronary intervention thrombolysis in myocardial infarction flow grade in patients with ST-segment elevation myocardial infarction after successful newer-generation drug-eluting stent implantation [0.03%]
基于PCI术前TIMI血流分级的ST段抬高型心肌梗死成功植入新一代药物洗脱支架患者的糖代谢状态差异性研究
Yong Hoon Kim,Ae-Young Her,Myung Ho Jeong et al.
Yong Hoon Kim et al.
Background: We compared the 2-year clinical outcomes between prediabetes and type 2 diabetes mellitus (T2DM) according to the pre-percutaneous coronary intervention (PCI) thrombolysis in myocardial infarction (TIMI) flow ...