Predation shapes the impact of cancer on population dynamics and the evolution of cancer resistance [0.03%]
捕食作用塑造了癌症对种群动态的影响及癌症抗性进化的过程
Cédric Perret,Cindy Gidoin,Beata Ujvari et al.
Cédric Perret et al.
Cancer is a widespread disease that affects most of the metazoans. However, cancer development is a slow process and, long before causing the death of the individual, may weaken organisms' capacities and impair their interactions with other...
The ecology and evolution of wildlife cancers: Applications for management and conservation [0.03%]
野生动物癌症的生态与进化：对管理和保护的应用
Rodrigo Hamede,Rachel Owen,Hannah Siddle et al.
Rodrigo Hamede et al.
Ecological and evolutionary concepts have been widely adopted to understand host-pathogen dynamics, and more recently, integrated into wildlife disease management. Cancer is a ubiquitous disease that affects most metazoan species; however, ...
Age-dependent expression of cancer-related genes in a long-lived seabird [0.03%]
长寿海鸟中与癌症相关基因的年龄依赖性表达
Richard Meitern,Jérôme Fort,Mathieu Giraudeau et al.
Richard Meitern et al.
Studies of model animals like mice and rats have led to great advances in our understanding of the process of tumorigenesis, but this line of study has less to offer for understanding the mechanisms of cancer resistance. Increasing the dive...
Evolution of tumor cells during AsiDNA treatment results in energy exhaustion, decrease in responsiveness to signal, and higher sensitivity to the drug [0.03%]
AsiDNA治疗期间肿瘤细胞的演化导致能量耗尽，对外界信号的反应降低以及对药物更高的敏感性
Pierre-Marie Girard,Nathalie Berthault,Maria Kozlac et al.
Pierre-Marie Girard et al.
It is increasingly suggested that ecological and evolutionary sciences could inspire novel therapies against cancer but medical evidence of this remains scarce at the moment. The Achilles heel of conventional and targeted anticancer treatme...
Elsa Hansen,Andrew F Read
Elsa Hansen
Cancer treatment is often aimed at achieving rapid, large, and sustained reductions in tumor burden. Even when these strong responses are achieved, treatment frequently fails due to the emergence of drug-resistant cell lineages. Over the la...
Agent-based modelling reveals strategies to reduce the fitness and metastatic potential of circulating tumour cell clusters [0.03%]
基于智能体的模拟揭示了减少循环肿瘤细胞团适应性和转移潜能的方法
Marco Campenni,Alexander N May,Amy Boddy et al.
Marco Campenni et al.
Metastasis-the ability of cancer cells to disperse throughout the body and establish new tumours at distant locations-is responsible for most cancer-related deaths. Although both single and clusters of circulating tumour cells (CTCs) have b...
Resolving Peto's paradox: Modeling the potential effects of size-related metabolic changes, and of the evolution of immune policing and cancer suppression [0.03%]
解决佩托悖论：建模与大小相关的代谢变化的潜在影响，以及免疫监控和癌症抑制的进化
Leonard Nunney
Leonard Nunney
The intrinsic risk of cancer increases with body size and longevity; however, big long-lived species do not exhibit this increase, a contradiction named Peto's paradox. Five hypotheses potentially resolving this paradox were modeled using t...
The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis [0.03%]
体细胞进化的三个维度：整合遗传损伤、生活史特征和老化在致癌作用中的作用
Andrii I Rozhok,James DeGregori
Andrii I Rozhok
Tumors result from genetic and epigenetic alterations that change cellular survival and differentiation probabilities, promoting clonal dominance. Subsequent genetic and selection processes in tumors allow cells to lose their tissue fidelit...
Robert Noble,John T Burley,Cécile Le Sueur et al.
Robert Noble et al.
The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not we...
Harnessing paleo-environmental modeling and genetic data to predict intraspecific genetic structure [0.03%]
利用古环境模型和遗传数据预测种内遗传结构
Glenn Yannic,Oskar Hagen,Flurin Leugger et al.
Glenn Yannic et al.
Spatially explicit simulations of gene flow within complex landscapes could help forecast the responses of populations to global and anthropological changes. Simulating how past climate change shaped intraspecific genetic variation can prov...